macrogol

Action and Spectrum

Actions and Spectrum 

Macrogol works by drawing water into the colon, softening the stool, and increasing its bulk. This facilitates bowel movements and helps alleviate constipation. 

Macrogol has hygroscopic properties thus it can attract and hold water molecules. This property is essential for its laxative action, as it helps to soften the stool.

Drug Interaction

Adverse Reaction

Frequency not defined  

Indigestion 

Bloating and wind 

Nausea 

Stomach pain or aches 

Diarrhea 

Vomiting 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals with a known allergy or hypersensitivity to macrogol or any of its components. 

Caution: 

• In cases of severe renal impairment, caution is advised.  
• Caution is advised when using macrogol in individuals with dehydration.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

The osmotic action of macrogol increases the volume of stool, promoting peristalsis and aiding in the movement of stool through the intestines. 

Pharmacodynamics 

The increased water content in the stool results in softer and bulkier stools. This softening effect makes it easier for the stool to move through the intestines and facilitates bowel movements. 

Pharmacokinetics 

Limited information available on ADME. 

Adminstartion

Administration 

Macrogol is administered orally, and it is available in the form of a powder. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: macrogol 

Why do we use macrogol? 

Macrogol is commonly used as an osmotic laxative.   

Macrogol is used to cleanse the bowel before medical procedures.