- March 15, 2022
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Brand Name :
Ludiomil
Synonyms :
maprotiline
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
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Brand Name :
Ludiomil
Synonyms :
maprotiline
Class :
Antidepressants and antianxiety drugs; norepinephrine reuptake inhibitors
Dosage forms & Strengths
Tablet
25 mg
50 mg
75 mg
Capsule
75mg
100mg
125mg
150mg
Outpatient
Initial dose 75 mg orally daily 2 weeks; may increase to 25 mg
Maximum dose is 150 mg daily
Maintenance dose: decrease dose to 75-150 mg orally daily if symptoms achieved in control
inpatient
100-150 mg orally daily 2 weeks
Do not exceed 225 mg daily
Safety and effecay not established
refer adult dosing
it increases the toxicity of norepinephrine re-uptake inhibitors
it increases the effect of serotonergic agents
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
anticholinergic agents decrease the efficacy of levosulpride
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
anticholinergic agents increase the ulcer-producing effect of potassium citrate
CNS depressants increase the CNS suppression effect of thalidomide
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the toxicity of norepinephrine reuptake inhibitors
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
glycopyrrolate inhaled and formoterol
may increase the QTc interval when combined
it increases the toxicity of norepinephrine reuptake inhibitors
Norepinephrine Reuptake Inhibitors increase arrhythmia, causing the effect of dronedarone
it increases the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the toxicity of norepinephrine reuptake inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
CNS depressants increase the CNS depressing effect of brexanolone
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the effect of CNS depressants
it increases the toxicity of serotonergic agents
it increases the effect of CNS depressants
anticholinergic agents increase the toxicity of topiramate
It may enhance sedation when combined with a shepherd's purse
maprotiline and dihydroergotamine intranasal are both known to elevate serotonin levels
it may enhance the sedation when combined with lofexidine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the toxicity of Norepinephrine Reuptake Inhibitors
norepinephrine reuptake inhibitors decrease the effect of guanethidine
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
anticholinergic agents increase the effect of constipation of clozapine
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of norepinephrine reuptake inhibitors
anticholinergic agents decrease the efficacy of secretin
CNS depressants increase the effect of zolpidem
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
they increase the metabolism of norepinephrine reuptake inhibitors
it increases the effect of norepinephrine reuptake inhibitors
Frequency undefined:
Fatigue
Lethargy
Sedation
Weakness
Constipation
Dry mouth
Blurred vision
Agitation
Anxiety
Headache
Insomnia
Nausea
Vomiting
Sweating
ECG changes
Tachycardia
Confusion
Extrapyramidal symptoms
Dizziness
Paresthesis
Tinnitus
Rash
Increased LFTs
Sexual dysfunction
Seizure
Agranulocytosis
Eosinophilia
Leukopenia
Thrombocytopenia
SIADH
Maprotiline is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.
Pregnancy consideration:
Category B.
Breastfeeding warnings:
Avoid taking the medication during breastfeeding
Pregnancy category:
Patient information leaflet
Generic Name: maprotiline
Pronounced: ma-pro-til-in
Why do we use maprotiline?
maprotiline is a tetracyclic antidepressant (TeCA) that is used for the treatment of depression. Here are some reasons why maprotiline may be prescribed:
maprotiline is primarily used for the treatment of depression. It works by affecting the levels of certain neurotransmitters in the brain, such as norepinephrine, which helps improve mood and alleviate symptoms of depression.
maprotiline may also be used to treat anxiety disorders such as generalized anxiety disorder (GAD). It can help reduce anxiety symptoms such as excessive worry, restlessness, and tension.
Off-label uses: In some cases, maprotiline may be used off-label for other conditions. For example, it may be prescribed to manage neuropathic pain or as a treatment for migraines.
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