masoprocol

Action and Spectrum

Actions and Spectrum 

Actions: 

• Antioxidant: masoprocol neutralizes harmful free radicals, protecting cells from oxidative stress and potential damage. 
• Anti-Inflammatory: It shows promise in reducing inflammation linked to various diseases. 
• Anticancer: masoprocol interferes with cancer cell growth, signal pathways, and apoptosis, potentially inhibiting cancer development. 

Spectrum: 

• Cancer Treatment: masoprocol is being studied for its potential to inhibit cancer cell growth, making it a candidate for anticancer therapy. 
• Skin Conditions: It might have applications in managing skin disorders like psoriasis due to its anti-inflammatory properties. 
• Antioxidant Support: masoprocol’s antioxidant properties could be beneficial in protecting cells from oxidative damage. 
• Lipid-Lowering Potential: Some research suggests it might impact cholesterol levels, but more investigation is needed. 

Drug Interaction

Adverse Reaction

Frequency defined 

>1% 

Skin irritation 

Inflammation 

Burning 

Edema 

Flaking 

Dryness 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity 

Cautions: 

• Interactions 
• Medical conditions 
• Monitoring 
• Side effects 
• Children 
• Pregnancy 
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy Category: B. 

Breastfeeding warnings:  

It is contraindicated during breastfeeding.  

Pregnancy category: 

Category A: Well-controlled and satisfactory studies show no risk to the fetus in the initial or later trimester. 

Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

masoprocol is a potent antioxidant, which can neutralize harmful molecules called free radicals. Free radicals are generated during normal cellular processes and can cause oxidative stress, contributing to various diseases and aging. By scavenging free radicals, masoprocol helps protect cells from oxidative damage. 

masoprocol has shown anti-inflammatory properties by modulating various inflammatory pathways. It can suppress the production of pro-inflammatory molecules, thus potentially reducing inflammation and its associated effects on the body. 

Pharmacodynamics: 

masoprocol’s anticancer effects involve interfering with cancer cell growth and survival. It affects cell cycle regulation, signal transduction pathways, and apoptosis (cell death). These actions collectively inhibit cancer cell proliferation and promote cell death. 

masoprocol inhibits enzymes involved in inflammation, including those that generate pro-inflammatory molecules. This inhibition helps regulate the body’s inflammatory responses. 

Pharmacokinetics: 

Absorption 

masoprocol is minimally absorbed (<2%) through the skin. 

Distribution 

masoprocol is distributed throughout the body’s tissues, potentially affecting various organs and systems. Its distribution depends on factors like its lipophilicity and molecular size. 

Metabolism 

masoprocol undergoes metabolic transformations, usually in the liver. Enzymes in the liver break down the compound into various metabolites. 

Elimination and Excretion 

Metabolites resulting from masoprocol’s breakdown are eventually eliminated from the body, primarily through urine. 

Adminstartion

Administration: 

masoprocol is administered topically as a cream. 

Refer your HCP for any adverse effects.

Patient Information Leaflet

Patient information leaflet 

Generic Name: masoprocol 

Pronounced as: mah-so-pro-kol 

Why do we use masoprocol? 

• Anti-Inflammatory Benefits: It can inhibit enzymes involved in inflammation, suggesting potential use in managing conditions where excessive inflammation plays a role. 
• Cancer Therapy: masoprocol has shown promise in inhibiting cancer cell growth, making it a research subject for potential cancer therapies. 
• Skin Disorder Management: Its anti-inflammatory effects make it a candidate for managing skin conditions like psoriasis, which involve inflammation.