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Brand Name :
Actinex
Synonyms :
masoprocol
Class :
Antineoplastics
Brand Name :
Actinex
Synonyms :
masoprocol
Class :
Antineoplastics
Dosage Forms & Strengths
Cream
10%
Apply to affected areas twice daily for 28 days
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Actions and Spectrum
Actions:
Spectrum:
Frequency defined
>1%
Skin irritation
Inflammation
Burning
Edema
Flaking
Dryness
Black Box Warning:
None
Contraindication/Caution:
Contraindications:
Cautions:
Pregnancy consideration:
Pregnancy Category: B.
Breastfeeding warnings:
It is contraindicated during breastfeeding.
Pregnancy category:
Category A: Well-controlled and satisfactory studies show no risk to the fetus in the initial or later trimester.
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
masoprocol is a potent antioxidant, which can neutralize harmful molecules called free radicals. Free radicals are generated during normal cellular processes and can cause oxidative stress, contributing to various diseases and aging. By scavenging free radicals, masoprocol helps protect cells from oxidative damage.
masoprocol has shown anti-inflammatory properties by modulating various inflammatory pathways. It can suppress the production of pro-inflammatory molecules, thus potentially reducing inflammation and its associated effects on the body.
Pharmacodynamics:
masoprocol’s anticancer effects involve interfering with cancer cell growth and survival. It affects cell cycle regulation, signal transduction pathways, and apoptosis (cell death). These actions collectively inhibit cancer cell proliferation and promote cell death.
masoprocol inhibits enzymes involved in inflammation, including those that generate pro-inflammatory molecules. This inhibition helps regulate the body’s inflammatory responses.
Pharmacokinetics:
Absorption
masoprocol is minimally absorbed (<2%) through the skin.
Distribution
masoprocol is distributed throughout the body’s tissues, potentially affecting various organs and systems. Its distribution depends on factors like its lipophilicity and molecular size.
Metabolism
masoprocol undergoes metabolic transformations, usually in the liver. Enzymes in the liver break down the compound into various metabolites.
Elimination and Excretion
Metabolites resulting from masoprocol’s breakdown are eventually eliminated from the body, primarily through urine.
Administration:
masoprocol is administered topically as a cream.
Refer your HCP for any adverse effects.
Patient information leaflet
Generic Name: masoprocol
Pronounced as: mah-so-pro-kol
Why do we use masoprocol?
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