mebhydrolin

Action and Spectrum

Actions and Spectrum: 

Action: 

Antihistamine: mebhydrolin is primarily classified as a first-generation antihistamine. It works by binding to and blocking histamine receptors in the body, thereby reducing the symptoms associated with histamine release. This action helps alleviate allergic reactions. 

Sedative: mebhydrolin also possesses sedative properties, which can induce drowsiness or sleepiness. This sedative effect can be beneficial for individuals experiencing allergy-related sleep disturbances. 

Spectrum: 

Allergic Rhinitis: mebhydrolin can relieve symptoms such as sneezing, runny nose, itching, and nasal congestion caused by allergic rhinitis (hay fever). 

Drug Interaction

Adverse Reaction

Frequency not defined  

sleep disturbances 

tremor 

myalgia 

blood disorders 

epigastric pain 

diarrhoea 

vomiting 

nausea 

constipation 

sweating 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: Do not use mebhydrolin if you are known to be hypersensitive or allergic to mebhydrolin or any of its components. Allergic reactions can be severe and life-threatening. 

Narrow-Angle Glaucoma: mebhydrolin may increase intraocular pressure, which can be dangerous for individuals with narrow-angle glaucoma. It’s important to avoid using it if you have this condition. 

Respiratory Depression: Avoid mebhydrolin in cases of severe respiratory depression, as it can further depress the respiratory system. 

Pregnancy and Breastfeeding: A healthcare professional should carefully consider and supervise mebhydrolin during pregnancy and breastfeeding. It may have potential risks to the developing fetus or infant. 

Children Under two Years: mebhydrolin is generally not recommended for use in children under two years old due to limited safety data in this age group. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

mebhydrolin is an antihistamine and anticholinergic medication that relieves allergy symptoms. 

Pharmacodynamics:  

Antihistamine:

mebhydrolin acts as an antagonist at H1 histamine receptors, blocking the effects of histamine. By blocking H1 receptors, mebhydrolin reduces the symptoms associated with allergies.   

Pharmacokinetics: 

Absorption 

mebhydrolin is usually administered orally in tablet or syrup form and is well-absorbed from the gastrointestinal tract. 

Distribution 

The drug, including the central nervous system (CNS), is distributed throughout the body. 

Metabolism 

mebhydrolin is metabolized in the liver, primarily through cytochrome P450 enzymes. 

Excretion and Elimination 

The metabolites and the unchanged drug are excreted in urine 

Adminstartion

Administration:  

The route of administration is oral. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: mebhydrolin 

Why do we use mebhydrolin?  

Relief from Allergic Symptoms: mebhydrolin is commonly prescribed to alleviate the symptoms associated with various allergies, including hay fever (allergic rhinitis), allergic conjunctivitis, and skin allergies. It helps reduce symptoms like sneezing, runny nose, itching, and watery eyes.