- May 13, 2022
- Newsletter
- 617-430-5616
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Brand Name :
No Data Available.
Synonyms :
meclofenamate
Class :
Nonsteroidal anti-inflammatory drug
Brand Name :
No Data Available.
Synonyms :
meclofenamate
Class :
Nonsteroidal anti-inflammatory drug
Dosage Forms & Strengths
Capsule
50mg
100mg
Dosage Forms & Strengths
Capsule
50mg
100mg
Refer adult dosing
choline magnesium trisalicylate
NSAIDs may enhance the adverse/toxic effect of Salicylates
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
may enhance the anticoagulant effect of Vitamin K Antagonists
it may enhance the adverse/toxic effect of apixaban
NSAIDs may enhance the anticoagulant effect of Heparin
NSAIDs may enhance the anticoagulant effect of Heparin
NSAIDs may increase the serum concentration of Lithium
NSAIDs may diminish the diuretic effect of loop diuretics
NSAIDs may diminish the diuretic effect of loop diuretics
NSAIDs may diminish the diuretic effect of loop diuretics
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
it may enhance the antiplatelet effect of Nonsteroidal Anti-Inflammatory Agents
interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity
interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity
acemetacin may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
Ketorolac may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
it May diminish the therapeutic effect of Loop Diuretics
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may diminish the antihypertensive effect of Beta-Blockers
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
NSAIDs may enhance the adverse/toxic effect of Bisphosphonate Derivatives
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
corticosteroids may enhance the adverse/toxic effect of NSAIDs
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDsmay diminish the antihypertensive effect of Potassium-Sparing Diuretics
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
NSAIDs May diminish the anti-hypertensive effect of Beta-Blockers
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
ACE Inhibitors may enhance the adverse/toxic effect of NSAIDs
It may enhance the toxicity when combined with mipomersen
it may increase the effect of serotonergic agents
Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of aliskiren
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
bile Acid Sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents
may diminish the therapeutic effect of angiotensin II Receptor Blockers
choline magnesium trisalicylate
may enhance the adverse/toxic effect of salicylates
NSAIDs may enhance the adverse/toxic effect of metformin
May diminish the effects of propranolol by pharmacodynamic antagonism
May diminish the effects by pharmacodynamic antagonism
when both drugs are combined, there may be an increased risk of adverse effects
Action
The primary action of meclofenamate is to inhibit the activity of the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. By blocking this enzyme, meclofenamate reduces inflammation and pain.
Spectrum
meclofenamate is frequently used to treat mild to moderate pain, including arthritis, menstrual cramps, headaches, and dental pain. meclofenamate helps lessen inflammation brought on by several illnesses, including gout, rheumatoid arthritis, and osteoarthritis. meclofenamate can also lessen fever by preventing the synthesis of prostaglandins that raise body temperature.
Frequency defined
>10%
Diarrhea (10-33%)
Nausea, with or without vomiting (11%)
1-10%
Headache (3-9%)
Edema (1-3%)
Pruritus (1-3%)
Urticaria (1-3%)
Tinnitus (1-3%)
Pyrosis (3-9%)
Flatulence (3-9%)
Rash (3-9%)
Dizziness (3-9%)
Anorexia (1-3%)
Constipation (1-3%)
Stomatitis (1-3%)
Peptic ulcer (1-3%)
Black Box Warning:
The black box warning for meclofenamate states that the drug may increase the risk of serious cardiovascular events, including heart attack and stroke, which can be fatal. The risk of these events may increase with prolonged use of meclofenamate and in people with existing cardiovascular disease or risk factors for cardiovascular disease, such as high blood pressure, diabetes, smoking, and high cholesterol levels.
The warning also states that meclofenamate can cause serious gastrointestinal side effects, such as bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Contraindication
Allergy: meclofenamate should not be taken by people who are allergic to it or to other NSAIDs because it can result in life-threatening adverse reactions.
Pregnancy: meclofenamate is not advised for usage during pregnancy, especially not in the third trimester when the foetus is still developing.
Active peptic ulcer disease: Those who have an active peptic ulcer disease, or a history of gastrointestinal bleeding shouldn’t take meclofenamate.
Caution
Cardiovascular disease: meclofenamate should be used with caution in individuals with a history of cardiovascular disease, as it can increase the risk of serious cardiovascular events.
Renal impairment: meclofenamate should be used with caution in individuals with renal impairment, as it can worsen kidney function nd cause kidney damage.
Hepatic impairment: meclofenamate should be used with caution in individuals with hepatic impairment, as it can worsen liver function and cause liver damage.
Asthma: meclofenamate should be used with caution in individuals with asthma, as it can exacerbate the condition and cause bronchospasm
Elderly: meclofenamate should be used with caution in elderly individuals, as they may be more susceptible to the drug’s side effects, such as gastrointestinal bleeding
Bleeding disorders: meclofenamate should be used with caution in individuals with bleeding disorders or taking blood thinners, as it can increase the risk of bleeding.
Dehydration: meclofenamate should be used with caution in individuals who are dehydrated or at risk of dehydration, as it can worsen kidney function and cause kidney damage.
Pregnancy consideration:
Pregnancy category: NA
Lactation: The excretion of drug into human milk is unknown