memantine/donepezil

DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse drug reactions:    

Frequency Defined  

>10% (donepezil)  

Accident (7-13%)  

Infection (11%)  

Insomnia (5-14%)  

Nausea (5-19%)  

Diarrhea (8-15%)  

1-10% (memantine)  

Confusion (6%)  

Cough (4%)  

Pain (3%)  

Syncope (3%)  

Dizziness (7%)  

Dyspnea (2%)  

Headache (6%)  

Constipation (5%)  

Fatigue (2%)  

Somnolence (3%)  

Hypertension (4%)  

Backache (3%)  

Vomiting (3%)  

1-10% (donepezil)  

Vomiting (3-8%)  

Cramping (3-8%)  

Headache (4-10%)  

Fatigue (3-8%)  

Pregnancy warnings:    
Pregnancy Category: B (memantine); C (donepezil)  

Lactation: Unknown  

Pregnancy Categories:       

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first trimester or the later trimester       
• Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women       
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits       
• Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women       
• Category N: There is no data available for the drug under this category      

  

Patient Information Leaflet    

Generic Name: memantine/donepezil 

Why do we use memantine/donepezil?  

memantine/donepezil belongs to the class of NMDA Antagonists helps to treat Alzheimer’s disease.