menadiol

Action and Spectrum

Actions and spectrum: 

Menadiol acts as an electron donor in submitochondrial particles for oxidative phosphorylation (reversed).  

This is necessary for the formation of prothrombin, factor IX and X. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Hemolysis  

Black Box Warning

Black Box Warning  

No special black box warning is available 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Infants 

Neonates 

Peri-natal period 

Galactosemia 

3rd trimester of pregnancy 

Precautions: 

Glucose-galactose malabsorption syndrome 

G6PD deficiency 

Deficiency of Vitamin E 

Lactose intolerance 

Chances of development of hyperbilirubinemia in premature infants and neonates 

Possibility of kernicterus in premature infants and neonates 

Possibility of hemolytic anemia in premature infants and neonates 

Pregnancy / Lactation

Pregnancy consideration:  

Menadiol is contraindicated in late phase or 3rd trimester of pregnancy 

Lactation:  

It is considered safe to use menadiol in lactation. 

Pregnancy categories:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category  

Pharmacology

Pharmacology: 

Menadiol, an organic compound, is obtained naturally by reducing menadione. 

Pharmacodynamics: 

Limited data available 

Pharmacokinetics: 

Limited data available 

Adminstartion

Administration: 

Menadiol tablets should be administered orally as suggested by the physician. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: menadiol 

Why do we use menadiol? 

Menadiol is an organic compound obtained naturally from menadione used to treat hemorrhage caused by low levels of prothrombin. It is also indicated for treating certain kinds of jaundice and preventing excessive bleeding.