Factors Influencing the Adoption of User-Administered Injectable Contraceptives in the United States
January 9, 2026
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Brand Name :
Frescolat X-cool
Synonyms :
menthyl ethylamido oxalate
Class :
Skin conditioner, cosmetic agent
Brand Name :
Frescolat X-cool
Synonyms :
menthyl ethylamido oxalate
Class :
Skin conditioner, cosmetic agent
Dosage Forms & Strengths
0.02% solution
Skin Conditioning
This is used to maintain our skin tone
Used as a skin conditioner
Strong cooling that is both immediate and long-lasting is offered by this agent: - Rapid skin reaction (within the first several minutes) - A powerful sense of freshness for 30 minutes; This is a liquid that is easy to work with and doesn't burn your tongue
Dose Adjustments
Limited data is available
Dosage Forms & Strengths
0.02% solution
Skin Conditioning
This is used to maintain our skin tone
Used as a skin conditioner
Strong cooling that is both immediate and long-lasting is offered by this agent: - Rapid skin reaction (within the first several minutes) - A powerful sense of freshness for 30 minutes; This is a liquid that is easy to work with and doesn't burn your tongue
Refer to the adult dosing
Actions and Spectrum:
Actions:
Menthyl ethylamido oxalate stimulates nerve endings, creating a perceived cooling effect on the skin and adjusts skin sensations, making it ideal for lotions, creams, and balms.
Spectrum:
Frescolat X-cool, derived from synthetic menthol, is a potent coolant offering intense freshness. It boasts a high safety profile, works effectively with mucosa, and is gentle on the skin.
Frequency not defined
Skin irritation
Sun sensitivity
Eye irritation
Allergic reactions
Black Box Warning:
Be careful when using products with menthyl ethylamido oxalate to avoid irritating sensitive areas like the eyes.
Contraindication/Caution:
Contraindications
Hypersensitivity
Cautions
Liver impairment
Sun sensitivity
Skin irritation
Allergic reactions
Pregnancy
Eyes irritation
Breastfeeding
Renal impairment
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Methyl ethylamido oxalate, from menthol, improves sensory experience in cosmetics by cooling the skin. It activates TRP channels, altering skin perception, mainly in lotions and creams.
Pharmacodynamics:
Menthyl ethylamido oxalate creates a cooling feeling by interacting with skin receptors, derived from menthol, used in skincare for its sensory effects, activating TRP channels when applied.
Pharmacokinetics:
Limited data is available
Administration:
Apply skincare products containing menthyl ethylamido oxalate directly onto the skin, spreading them over the desired area.
Patient information leaflet
Generic Name: menthyl ethylamido oxalate
Pronounced: MEN-thil ETH-il-AM-i-do OK-suh-late
Why do we use menthyl ethylamido oxalate?
Menthyl ethylamido oxalate is used in skincare and cosmetics for its cooling effect, commonly found in lotions, creams, and balms for a refreshing sensation.
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