mepartricin

Action and Spectrum

Actions and Spectrum: 

Action: 

mepartricin acts selectively against fungal pathogens and is particularly effective against a wide range of dermatophytes, yeast, and molds. Its mechanism of action makes it a fungicidal agent, meaning it directly kills fungal cells rather than simply inhibiting their growth. This property enhances its therapeutic efficacy in treating various fungal infections.  

Spectrum: 

Dermatophytes: mepartricin is highly effective against dermatophytes such as Trichophyton, Microsporum, and Epidermophyton species. These fungi are responsible for common skin infections, including ringworm, athlete’s foot, and jock itch. 

Yeast: Candida species, including Candida albicans, are susceptible to the fungicidal action of mepartricin. It manage mucocutaneous candidiasis, vaginal candidiasis, and other yeast-related infections. 

Drug Interaction

Adverse Reaction

Frequency not defined  

nausea 

Constipation 

Dyspepsia 

Gastralgia 

vomitting 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: mepartricin should not be administered to individuals with a known hypersensitivity or allergy to the active ingredient or any components of the drug formulation.  

Pregnancy and Lactation: The safety of mepartricin has not received sufficient research attention concerning its effects during pregnancy and lactation. Consequently, potential hazards to the developing fetus or nursing baby may exist. As a result, the use of mepartricin in pregnant and breastfeeding women is not recommended unless a healthcare provider determines that the potential advantages outweigh the potential risks. 

Systemic Fungal Infections: mepartricin is contraindicated in patients with systemic fungal infections. This is because the drug is intended for topical use and is ineffective against systemic fungal infections that affect internal organs or tissues. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

mepartricin is employed in the treatment of various fungal and bacterial infections. 

Pharmacodynamics:  

mepartricin functions as an antifungal agent by interfering with the synthesis of ergosterol, a crucial component of the fungal cell membrane. mepartricin inhibits the enzyme squalene epoxidase, a critical step in ergosterol biosynthesis, resulting in the depletion of ergosterol levels. This disruption in the fungal cell membrane structure compromises its permeability, leading to cell lysis and death.  

Pharmacokinetics: 

N/A 

Adminstartion

Administration:  

The route of administration is oral. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: mepartricin 

Why do we use mepartricin?  

Antifungal Activity: mepartricin exhibits potent antifungal properties, making it valuable in managing fungal infections. mepartricin treats fungal infections, such as dermatophytosis, candidiasis, and certain systemic mycoses. 

Topical Dermatological Preparations: The antifungal capabilities of mepartricin make it a common ingredient in topical dermatological formulations. These formulations treat superficial fungal infections of the skin, nails, and mucous membranes.