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Brand Name :
N/A
Synonyms :
Merigolix
Class :
Gonadotrophin releasing hormone (GnRH) antagonist
Brand Name :
N/A
Synonyms :
Merigolix
Class :
Gonadotrophin releasing hormone (GnRH) antagonist
Dosage Forms & Strengths
Gonadotropin-Releasing Hormone Deficiency In Adults
Investigational drug
Under clinical trials; Phase I trials have been completed.
Dosage Forms & Strengths
Safety and efficacy not established.
Refer adult dosing.
Actions and Spectrum:
Merigolix blocks the GnRH receptors by inhibiting the LH and FSH hormone release that controls the progestrone and estrogen synthesis. Therefore it is used in controlled ovarian stimulation to prevent premature ovulation and ensure retrieval.
Frequency not defined
None of them have been reported
Black box warning:
None
Contraindications/caution:
There is no documented data
Pregnancy/Lactation
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Merigolix that disrupts the reproductive system by affecting FSH and LH release.
Pharmacokinetics:
There is no data available
Administration:
There is no accurate and current information on the administration of Merigolix.
Patient information leaflet
Generic Name: merigolix
Why do we use Merigolix?
Merigolix is a GnRH antagonist which inhibits Gonadotropin releasing hormone important for endometriosis, prostate cancer and uterine fibroids.
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