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Brand Name :
N/A
Synonyms :
Merigolix
Class :
Gonadotrophin releasing hormone (GnRH) antagonist
Dosage Forms & StrengthsÂ
Gonadotropin-Releasing Hormone Deficiency In AdultsÂ
Investigational drug
Under clinical trials; Phase I trials have been completed.
Dosage Forms & StrengthsÂ
Safety and efficacy not established.Â
Refer adult dosing.Â
Actions and Spectrum:Â
Merigolix blocks the GnRH receptors by inhibiting the LH and FSH hormone release that controls the progestrone and estrogen synthesis. Therefore it is used in controlled ovarian stimulation to prevent premature ovulation and ensure retrieval. Â
Frequency not definedÂ
None of them have been reportedÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
There is no documented dataÂ
Pregnancy/LactationÂ
Pregnancy consideration: Insufficient data availableÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this categoryÂ
Pharmacology:Â
Merigolix that disrupts the reproductive system by affecting FSH and LH release.Â
Pharmacokinetics:Â
There is no data availableÂ
Administration:Â
There is no accurate and current information on the administration of Merigolix.Â
Patient information leafletÂ
Generic Name: merigolixÂ
Why do we use Merigolix?Â
Merigolix is a GnRH antagonist which inhibits Gonadotropin releasing hormone important for endometriosis, prostate cancer and uterine fibroids. Â