metenolone

Action and Spectrum

Actions and Spectrum: 

Action: 

metenolone, a synthetic anabolic-androgenic steroid (AAS), exerts its actions primarily through interaction with androgen receptors in various tissues. Compared to many other AAS, it has a relatively mild and balanced profile regarding its anabolic (muscle-building) and androgenic (masculinizing) effects. The anabolic effects of metenolone include increased protein synthesis and nitrogen retention, which promote the growth and preservation of lean muscle mass.

This makes it valuable when muscle wasting or lean tissue loss is a concern, such as in certain medical conditions like HIV-related wasting syndrome or post-surgery recovery. The androgenic effects of metenolone, while less pronounced than some other steroids, can lead to secondary sexual characteristic changes like facial hair growth and voice deepening, particularly at higher doses. metenolone is less likely to convert to estrogen, reducing the risk of estrogen-related side effects such as water retention or gynecomastia. 

Spectrum: 

The spectrum of metenolone’s use is relatively limited, primarily due to its mild anabolic properties compared to other AAS. It is not considered a potent performance-enhancing drug and is less commonly used in bodybuilding or athletics when rapid and substantial muscle gains are sought. Instead, metenolone is more commonly utilized in medical settings, including treating anemia, muscle wasting conditions, and osteoporosis. Its mild androgenic nature makes it suitable for specific patient populations, including women and individuals who may be more sensitive to androgenic side effects.

Drug Interaction

Adverse Reaction

Frequency not defined 

Hypercalcaemia 

Hirsutism 

Psychiatric effects 

Male pattern baldness 

Prostatic hypertrophy 

Fluid and electrolyte retention 

Gynaecomastia 

Cholestatic jaundice 

Oedema 

Azoospermia 

Virilisation 

Increased bone growth and skeletal weight 

Acne 

Amenorrhoea 

Menstrual irregularities 

Priapism 

Seborrhoea 

Impotence 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication 

• Hypersensitivity or Allergy: Individuals with known hypersensitivity or allergies to metenolone or its components should not use this medication. 
• Prostate Cancer: metenolone is an androgenic compound, and its use is contraindicated in individuals with prostate cancer or a history of prostate cancer. AAS can stimulate the growth of prostate tissue, potentially worsening the condition. 
• Breast Cancer: metenolone is also contraindicated in individuals with breast cancer. Like prostate cancer, breast tissue can be sensitive to AAS-induced hormonal changes. 
• Pregnancy and Breastfeeding: metenolone should not be used by pregnant or breastfeeding women. It can have masculinizing effects on a developing fetus (virilization) and may pass into breast milk, affecting a nursing infant. 
• Children and Adolescents: metenolone is generally not recommended for use in children or adolescents, as it can interfere with average growth and development and may cause premature closure of growth plates. 
• Liver Disease: The liver metabolizes metenolone, especially the oral form (metenolone acetate). It can put the additional strain on the liver, and individuals with pre-existing liver disease should avoid its use or use it under strict medical supervision. 
• Cardiovascular Issues: Individuals with a prior history of cardiovascular disease, including heart attacks or stroke, should use metenolone cautiously, as AAS can adversely affect lipid profiles and cardiovascular risk factors. 
• Hypercalcemia: metenolone may exacerbate conditions associated with hypercalcemia (elevated calcium levels in the blood), such as hyperparathyroidism. 
• Renal Impairment: People with severe renal impairment should be cautious when using metenolone, as it can affect electrolyte balance and fluid retention. 
• Hepatic Impairment: Individuals with severe hepatic impairment should avoid using metenolone due to its potential impact on liver function. 
• Psychiatric Conditions: AAS, including metenolone, can have mood-altering effects and may exacerbate underlying psychiatric conditions such as depression, anxiety, and aggression. Individuals with a history of the mental health issues should use caution when considering AAS. 
• Athletic and Non-Medical Use: The non-medical use of metenolone for performance enhancement is generally discouraged and often illegal in many sports organizations and countries because of its classification as a controlled substance. Athletes should be aware of the doping regulations and potential consequences. 

Caution 

• Medical Supervision: metenolone should only be used under the supervision of the qualified healthcare provider who can monitor your progress, assess the appropriateness of treatment, and manage potential side effects. 
• Dosage and Duration: It is essential to adhere to the prescribed dosage and treatment duration. Avoid self-adjusting the dose or extending the treatment without medical guidance, as this can increase the risk of side effects. 
• Monitoring: Regular medical check-ups, including blood tests, should be conducted to monitor your response to metenolone and detect any adverse effects or changes in health. 
• Cardiovascular Health: metenolone, like other AAS, can affect lipid profiles and cardiovascular risk factors. If you have a history of cardiovascular disease or risk factors such as high BP or high cholesterol, use metenolone with caution and consider regular cardiovascular monitoring. 
• Liver Health: The liver metabolizes metenolone, particularly the oral form (metenolone acetate). Individuals with liver disease or impaired liver function should use metenolone cautiously or avoid it altogether. 
• Psychological Effects: AAS, including metenolone, can have mood-altering effects, including increased aggression and irritability. Discuss the potential psychological effects with your healthcare provider if you have a history of psychiatric conditions. 
• Dependency and Withdrawal: Some individuals may develop psychological dependence on AAS. Abrupt discontinuation of metenolone can lead to withdrawal symptoms. Tapering the dose under medical supervision may be necessary to mitigate withdrawal effects. 
• Virilization Risk (Females): Female users of metenolone should be aware of the risk of virilization, which includes the development of the male secondary sexual characteristics, like the deepening of the voice, facial hair growth, and clitoral enlargement. If signs of virilization occur, discontinue use immediately and consult a healthcare provider. 
• Growth Plates (Adolescents): Adolescents using metenolone should be closely monitored because AAS use can lead to premature closure of growth plates, potentially limiting height growth. 
• Pregnancy and Breastfeeding: metenolone should be avoided during pregnancy condition and breastfeeding due to the potential for virilization effects on the fetus or nursing infant. 
• Drug Interactions: Inform your healthcare provider of any other medications or supplements you are taking, as metenolone may interact with other drugs. 
• Athletic and Non-Medical Use: The non-medical use of metenolone for performance enhancement is discouraged and often illegal in many sports organizations and countries due to its classification as a controlled substance. Athletes should be aware of the doping regulations and potential consequences. 

Pregnancy / Lactation

Pregnancy consideration:  

Category  

Breastfeeding warnings:  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

metenolone, a synthetic anabolic-androgenic steroid (AAS), exerts its pharmacological effects primarily by binding to androgen receptors in various tissues, including muscle cells. This binding activates specific signaling pathways that increase protein synthesis and nitrogen retention, enhancing muscle growth and lean body mass. metenolone exhibits a relatively low level of androgenic activity, contributing to its mild anabolic effects and reduced risk of virilization in women compared to other AAS. Additionally, it does not readily aromatize into estrogen, reducing the likelihood of estrogen-related side effects. 

Pharmacodynamics: 

Mechanism of action: metenolone, also known as methenolone, is a synthetic anabolic-androgenic steroid (AAS) that exerts its effects primarily through interactions with androgen receptors in various tissues. Its mechanism of action is similar to that of other AAS, but metenolone is relatively mild in terms of its anabolic and androgenic effects compared to some other AAS.  

• Binding to Androgen Receptors: metenolone enters cells and binds to androgen receptors, which are found in the  various tissues throughout the body, including muscle cells. 
• Activation of Androgen Receptors: Upon binding to androgen receptors, metenolone activates these receptors, leading to conformational changes in the receptor protein. 
• Translocation to the Nucleus: Activated androgen receptors translocate into the nucleus from the cell’s cytoplasm. 
• Gene Expression Regulation: Once in the nucleus, activated androgen receptors interact with specific DNA sequences, known as androgen response elements (AREs), within target genes. This interaction leads to the changes in gene expression, resulting in various cellular responses. 
• Anabolic Effects: metenolone’s activation of androgen receptors in muscle tissue promotes protein synthesis, nitrogen retention, and increased lean muscle mass. This is responsible for its anabolic effects. 
• Androgenic Effects: While metenolone is relatively mild in its androgenic properties, it can still exert some androgenic effects, such as influencing secondary sexual characteristics, including body hair growth and voice deepening, particularly at higher doses. 
• Effects on Other Tissues: Androgen receptors exist in other tissues, including skin, hair follicles, and sebaceous glands. Activation of these receptors can lead to changes in these tissues, which may contribute to side effects associated with metenolone use. 

Pharmacokinetics: 

Absorption 

When taken orally, metenolone acetate is absorbed through the gastrointestinal tract. It undergoes first-pass metabolism in the liver, which can reduce its bioavailability. This means that only a portion of the ingested dose reaches systemic circulation. 

Distribution 

Once in the bloodstream, metenolone is distributed throughout the body. Like other steroids, it may bind to proteins in the blood, including albumin and sex hormone-binding globulin (SHBG). 

Metabolism 

The metabolism of metenolone primarily occurs in the liver. It is metabolized through various enzymatic pathways. Some of the metabolites produced during this process may contribute to the pharmacological effects of metenolone. 

Elimination and Excretion 

The excretion of metenolone and its metabolites primarily occurs through the kidneys. Unchanged metenolone, as well as its metabolites, can be excreted in the urine. 

Adminstartion

Administration: 

metenolone is available in two primary forms: oral and injectable. The administration and dosing instructions can vary based on the specific form you are using and the medical condition for which it has been prescribed. Following your healthcare provider’s guidance and the medication’s label instructions is essential.  

Dosage: The suggested dosage can vary depending on the medical condition being treated.  

Injection Sites: Injections are commonly administered into the gluteal muscle (buttocks) or the deltoid muscle (shoulder). 

Frequency: metenolone is usually taken once daily. However, your provider may recommend a different dosing schedule. 

Timing: It is typically taken with meals to help minimize potential gastrointestinal discomfort. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: metenolone 

Why do we use metenolone? 

metenolone is a synthetic anabolic-androgenic steroid (AAS). Its medical uses are limited and relatively rare due to concerns about side effects and the availability of alternative treatments. It has primarily been used in the treatment of certain medical conditions.  

• Anemia: metenolone has been used to treat anemia associated with bone marrow failure. It can help stimulate red blood cell production and increase hemoglobin levels, potentially improving symptoms of anemia. 
• Wasting Syndromes: metenolone may be prescribed to individuals with severe weight loss and muscle-wasting conditions, such as HIV-related wasting syndrome. It can help improve lean body mass and overall well-being. 
• Osteoporosis: In some cases, metenolone has been considered a treatment option for osteoporosis, a condition characterized by weakened bones.  
• Preoperative Nutrition: metenolone has been used to improve nutritional status in individuals who are malnourished or require preoperative nutritional support. 
• Trauma and Surgery Recovery: In specific medical scenarios, metenolone has been used to help patients recover from trauma, surgery, or other situations where muscle tissue loss has occurred.