- March 15, 2022
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Brand Name :
Celontin
Synonyms :
methsuximide
Class :
Anticonvulsants, Succinimide
Dosage Forms & Strengths
Capsule
150 mg
300 mg
Dosage Forms & Strengths
Capsule
150 mg
300 mg
Refer to adult dosing
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
Actions and Spectrum
methsuximide exerts its anticonvulsant effects by acting on the central nervous system (CNS). By inhibiting these channels, it reduces the abnormal electrical activity that leads to seizures.
Frequency not defined
Serious
Auditory hallucinations, suicidal behavior, psychotic disorder (all rare)
Systemic lupus erythematosus
Stevens-Johnson syndrome
Disorder of hematopoietic structure, pancytopenia, leukopenia, monocytosis
Common
Abdominal pain, weight loss, epigastric pain, loss of appetite, nausea, constipation, diarrhea vomiting
Ataxia, somnolence, dizziness
Hematuria, proteinuria
Erythema
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The anticonvulsant effects primarily block T-type calcium channels in the thalamus. These channels are involved in the generation of burst firing, which is associated with abnormal neuronal activity seen in absence seizures.
Pharmacodynamics
When compared to other seizure types, methsuximide displays a higher level of specificity for treating absence seizures. The partial seizures are less responsive to treatment.
Pharmacokinetics
Absorption
methsuximide is absorbed from the gastrointestinal tract after oral administration.
Distribution
methsuximide is distributed throughout the body and has a moderate volume of distribution.
Metabolism
methsuximide undergoes hepatic metabolism.
Elimination and excretion
methsuximide and its active metabolite are eliminated through the urine.
Administration
methsuximide is administered orally in the form of capsules.
Patient information leaflet
Generic Name: methsuximide
Why do we use methsuximide?
In both adults and children, methsuximide is used to treat absence seizures, often known as ‘petit mal’ seizures.
It is recommended as a first-line treatment for absence seizures and is often used in combination with other antiepileptic drugs.
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