Insurance Can Decide Survival for Young Cancer Patients
April 2, 2026
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
N/A
Synonyms :
methylthioninium
Class :
Detoxifying Agents, Substance dependence drugs
Brand Name :
N/A
Synonyms :
methylthioninium
Class :
Detoxifying Agents, Substance dependence drugs
Dosage Forms & Strengths
Solution
0.5%
1%
Administer dose of 1 to 2 mg/kg through slow injection for 5 minutes
Maximum total dose should not be more than 7 mg/kg for one treatment
Dosage Forms & Strengths
Solution
0.5%
For newborn to 3 months infants:
Administer dose of 0.3 to 0.5 mg/kg through slow injection for 5 minutes
For >3 months old:
Administer dose of 1 to 2 mg/kg through slow injection for 5 minutes
Refer to adult dosing
Actions and Spectrum
Methemoglobin is a form of hemoglobin that cannot bind oxygen effectively.
Methylthioninium acts as a reducing agent, converting methemoglobin back to normal hemoglobin, thereby restoring the oxygen-carrying capacity of the blood.
Frequency not defined
Hypersensitivity
Nausea
Tachycardia
Cardiac arrhythmia
Abdominal pain
Dysgeusia
Chest pain
Mydriasis
Pain in extremity
Dizziness
Headache
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Methylthioninium is a redox-active compound. It acts as a reducing agent and is involved in electron transfer reactions.
Methylthioninium has antioxidant properties, and it can scavenge free radicals.
Pharmacodynamics
Methylthioninium inhibits the activity of monoamine oxidase, an enzyme responsible for the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine.
Pharmacokinetics
Absorption
Methylthioninium is absorbed from the gastrointestinal tract.
Distribution
Methylthioninium is distributed in the tissue.
Metabolism
Methylthioninium undergoes first pass metabolism.
Elimination and excretion
Methylthioninium is excreted via urine.
Administration
Methylthioninium is administered intravenously.
Patient information leaflet
Generic Name: methylthioninium
Why do we use methylthioninium?
Methylthioninium is used in treatment for methemoglobinemia, a condition in which an abnormal form of hemoglobin.
Methylthioninium is used in photodynamic therapy, a treatment that involves the activation of a photosensitizing agent by light
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
