Action and Spectrum

Actions and Spectrum: 

meticrane is a pharmaceutical prescribed as a diuretic and antihypertensive agent. Its mode of operation revolves around the inhibition of sodium and chloride ion reabsorption within the distal convoluted tubule, leading to lowered blood pressure. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Black Box Warning

Black Box Warning:  

None  

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity to Active Ingredients: People who have a known hypersensitivity or allergic response to any of the active components found in meticrane should avoid using it. Prior medical consultation is recommended in such cases to explore alternative treatment options. 

Monoamine Oxidase Inhibitors (MAOIs) Interaction: Concurrent administration of meticrane with monoamine oxidase inhibitors or within a minimum duration following the discontinuation of MAOIs is contraindicated due to the potential for severe hypertensive crises and adverse reactions.  

Severe Cardiovascular Conditions: Individuals suffering from severe cardiovascular conditions, such as significant heart arrhythmias, unstable angina, myocardial infarction are contraindicated from using meticrane due to the potential exacerbation of cardiac symptoms. 

Renal Impairment: meticrane should be used cautiously in patients with severe renal impairment, as the excretion of its components may be altered. Dosage adjustment or an alternative treatment approach might be necessary in such cases. 

Hepatic Dysfunction: Patients with severe hepatic impairment are advised to avoid meticrane usage, as the metabolism and elimination of the drug might be compromised. A thorough assessment of hepatic function is recommended before considering meticrane therapy. 

Pregnancy and Lactation: meticrane usage is generally not recommended during pregnancy and lactation due to limited safety data. The potential risks and benefits should be carefully evaluated in consultation with a healthcare professional. 

Pediatric Population: meticrane is not indicated for pediatric use, and its administration to children under a certain age is contraindicated. Pediatric patients necessitate alternative treatment options under the guidance of a qualified medical practitioner. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

meticrane is a pharmaceutical prescribed as a diuretic and antihypertensive agent. 

Pharmacodynamics:  

meticrane is a pharmaceutical prescribed as a diuretic and antihypertensive agent. Its mode of operation revolves around the inhibition of sodium and chloride ion reabsorption within the distal convoluted tubule, leading to lowered blood pressure. 

Pharmacokinetics:  

Absorption 

meticrane is administered orally and is rapidly absorbed from the gastrointestinal tract.  

Distribution 

meticrane is distributed throughout the body, including the kidneys, liver, and heart.  

Metabolism 

meticrane is metabolized in the liver by the cytochrome P450 system.   

Excretion and Elimination 

meticrane and its metabolites are excreted primarily in the urine.

Adminstartion

Administration:  

The administration is by oral route. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: meticrane 

Why do we use meticrane?  

Reducing elevated blood pressure: meticrane serves the purpose of diminishing high blood pressure, thereby aiding in the mitigation of complications linked to hypertension. 

Management of essential hypertension: meticrane is uniquely prescribed for addressing essential hypertension, a condition characterized by high blood pressure of unknown origin.