moperone

Action and Spectrum

Actions and Spectrum: 

• Dopamine Receptor Antagonism: moperone primarily acts as a dopamine D2 receptor antagonist. It competes with dopamine for binding to these receptors in the central nervous system. By blocking dopamine’s action at these receptors, moperone helps modulate dopaminergic neurotransmission. This is important because imbalances in dopamine activity are implicated in various psychiatric disorders. 
• Serotonin Receptor Antagonism: moperone may also exhibit antagonistic effects on serotonin receptors, particularly 5-HT2 receptors. This additional activity can contribute to its overall therapeutic effects. 

Drug Interaction

Adverse Reaction

N/A 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Contraindications: 

Hypersensitivity or Allergy: Individuals with known hypersensitivity or allergy to moperone or other butyrophenones should avoid its use. 

Caution: 

• Elderly Patients: Use caution when prescribing moperone to elderly individuals, as they may be more susceptible to side effects such as sedation and orthostatic hypotension. 
• Cardiovascular Conditions: Monitor patients with cardiovascular conditions for potential side effects, including orthostatic hypotension. Consider the cardiovascular status before initiating moperone. 
• Seizure Disorders: moperone may lower the seizure threshold. Use caution in individuals with a history of seizure disorders, and closely monitor for any changes. 

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

• Dopamine Receptor Antagonism: moperone primarily acts as a dopamine D2 receptor antagonist. It competes with dopamine for binding to these receptors in the central nervous system. By blocking dopamine’s action at these receptors, moperone helps modulate dopaminergic neurotransmission. This is important because imbalances in dopamine activity are implicated in various psychiatric disorders. 
• Serotonin Receptor Antagonism: moperone may also exhibit antagonistic effects on serotonin receptors, particularly 5-HT2 receptors. This additional activity can contribute to its overall therapeutic effects. 

Pharmacokinetics: 

N/A 

Adminstartion

Administration: 

Oral administration 

moperone is usually taken by mouth (orally). 

Patient Information Leaflet

Patient information leaflet 

Generic Name: moperone 

Why do we use moperone? 

moperone is an anti-psychotic medication primarily used in the treatment of psychiatric disorders. Here are some of the common uses of moperone: 

• Schizophrenia: moperone is prescribed for the treatment of schizophrenia, a severe mental disorder characterized by disturbances in thought processes, emotions, and behavior. 
• Psychotic Disorders: It may be used in the management of other psychotic disorders, including schizoaffective disorder. Moperone helps alleviate symptoms such as hallucinations, delusions, and disorganized thinking. 
• Agitation and Behavioral Disturbances: moperone’s sedative properties make it useful in managing agitation and behavioral disturbances associated with psychiatric conditions. 

Anxiety and Agitation in the Elderly: In some cases, moperone may be utilized to address anxiety and agitation in the elderly population.