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November 27, 2025
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Brand Name :
Naftin
Synonyms :
naftifine
Class :
Antifungals, Topicals
Brand Name :
Naftin
Synonyms :
naftifine
Class :
Antifungals, Topicals
Dosage Forms & Strengths
Topical gel
2%
1%
Topical cream
2%
1%
Indicated for Dermatophytoses
1% topical gel or cream: two times a day, topically apply near the affected area with an extra 0.5-inch of healthy skin for about four weeks
2% topical gel or cream: one time a day, topically apply near the affected area with an extra 0.5-inch of healthy skin for about two weeks
Note:
2% topical gel or cream: It is generally indicated for therapy of interdigital tinea pedis, tinea corporis, and tinea cruris by Trichophyton rubrum
1% topical gel: It is generally indicated for the therapy of tinea pedis, tinea corporis, and tinea cruris by Trichophyton rubrum, Trichophyton Tonsurans, Epidermophyton floccosum, and Trichophyton mentagrophytes
1% topical cream: It is generally indicated for the therapy of tinea pedis, tinea corporis, and tinea cruris by Trichophyton rubrum, Epidermophyton floccosum, and Trichophyton mentagrophytes
Dosage Forms & Strengths
Topical gel
2%
Topical cream
2%
Indicated for Tinea Pedis
Age 12-17 years
2% topical gel or cream: one time a day, topically apply near the affected area with an extra 0.5-inch of healthy skin for about two weeks
Age <12 years
Safety and efficacy not established
2% topical gel or cream: It is generally indicated for therapy of interdigital tinea pedis by Trichophyton rubrum
Tinea Cruris
Age 12-17 years
2% topical cream: one time a day, topically apply near the affected area with an extra 0.5-inch of healthy skin for about two weeks
Age <12 years
Safety and efficacy not established
It is generally indicated for the therapy of tinea cruris by Trichophyton rubrum
Tinea Corporis
Age >2 years
1% topical cream: one time a day, topically apply near the affected area with an extra 0.5-inch of healthy skin for about two weeks
Age <2 years
Safety and efficacy not established
It is generally indicated for the therapy of tinea corporis by Trichophyton rubrum
Refer to adult dosing
Actions and Spectrum:
naftifine is an antifungal medication commonly used to treat various fungal skin infections, like athlete’s foot, jock itch, and ringworm. It generally belongs to the class of drugs known as allylamines and works by inhibiting the synthesis of ergosterol, a important component of the fungal cell membrane.
naftifine interferes with the enzyme squalene epoxidase, which converts squalene to lanosterol in the fungal cell membrane synthesis pathway. By inhibiting this enzyme, naftifine disrupts the production of ergosterol, forming abnormal and defective fungal cell membranes. This disruption weakens the integrity of the fungal cells, causing their death and subsequent elimination.
naftifine has a broad spectrum of activity against various fungi, including dermatophytes (e.g., Trichophyton species, Microsporum species, Epidermophyton floccosum), as well as specific yeasts (e.g., Candida species) and other fungi.
It is important to note that while naftifine is primarily used for topical application in creams, gels, or sprays, it can also be available in oral or systemic formulations for some instances. The specific usage, dosage, and duration of treatment might vary depending on the type and severity of the fungal infection, so it’s always recommended to follow the instruction provided by your healthcare professional or the product labeling.
Frequency defined
1-10%
Erythema
Pruritus
Dryness
Local irritation
Rash
Stinging
Transient burning
Skin tenderness (0.5-3%)
Black Box Warning:
None
Contraindication/Caution:
Contraindication
naftifine has a few contraindications, which are situations where medication use is not recommended due to potential risks or interactions. Some contraindications of naftifine include:
It’s key to consult with a healthcare professional or read the product labeling for specific contraindications and precautions associated with naftifine, as these may vary depending on the formulation and brand.
Caution
While there may not be specific black box warnings for naftifine, several cautions and precautions should be considered when using this medication. These include:
Pregnancy consideration:
US FDA pregnancy category: Not assigned
Lactation:
Excreted into human milk is Not known.
Breastfeeding warnings:
Pregnancy category:
Pharmacology:
naftifine is an antifungal medication that belongs to the allylamine class of drugs. It generally works by inhibiting the synthesis of ergosterol, a important component of the fungal cell membrane.
naftifine exerts its antifungal activity by inhibiting the enzyme squalene epoxidase. This enzyme converts squalene to lanosterol, a crucial step in synthesizing ergosterol. By blocking squalene epoxidase, naftifine disrupts the production of ergosterol, leading to the formation of defective fungal cell membranes and subsequent cell death.
Pharmacodynamics:
Mechanism of action: The action of naftifine involves its ability to inhibit the synthesis of ergosterol, a important component of the fungal cell membrane. Here’s a detailed explanation of the mechanism:
Pharmacokinetics:
Absorption
When naftifine is applied topically on the skin, it is minimally absorbed into the systemic circulation. The absorption can vary depending on factors such as the formulation, the site of application, and the integrity of the skin. Generally, most of the drug remains localized at the site of application, providing targeted treatment for fungal skin infections.
Distribution
After absorption, naftifine has a limited distribution within the body. It primarily remains in the skin and underlying tissues, exerting its antifungal activity. naftifine is not known to distribute to other organs or tissues extensively.
Metabolism
naftifine undergoes hepatic metabolism in the liver. It is metabolized by various enzymes into inactive metabolites, including cytochrome P450 (CYP) enzymes. The specific metabolic pathways and enzymes involved in the metabolism of naftifine have yet to be extensively studied.
Elimination and Excretion
The metabolites of naftifine and any unmetabolized drug are generally eliminated from the body through urine and feces. The exact proportion of elimination via each route has yet to be established.
Administration:
Topical administration
naftifine is typically available as a topical cream, gel, or spray formulation for treating fungal infections on the skin. The following guidelines can help with the administration of naftifine:
Patient information leaflet
Generic Name: naftifine
Pronounced: [ NAF-ti-feen-TOP-ik-al ]
Why do we use naftifine?
naftifine is primarily used for the treatment of various fungal infections of the skin. Some common uses of naftifine include:
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