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naproxen - medtigo

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naproxen

Brand Name :

Anaprox, Naprosyn, Naproxen EC, Aleve, EC Naprosyn, naprox sodium

Synonyms :

Naprolag, naproxen, naproxeno

Class :

Non-steroidal anti-inflammatory drugs





No data available for drug.

Mechanism of action

It is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins, chemicals in the body that cause inflammation and pain. Its action inhibits cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By inhibiting these enzymes, naproxen reduces the production of prostaglandins and thus reduces inflammation and pain

Spectrum

The spectrum of naproxen activity includes treating pain, inflammation, and fever. It is commonly used to treat rheumatoid arthritis, osteoarthritis, gout, and menstrual cramps. It can also alleviate pain caused by injuries, such as sprains and strains, and reduce fever

DRUG INTERACTION

naproxen

&

  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • rabies immune globulin, human (RIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone (Pending FDA Approval)
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid (Pending FDA Approval)
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitnib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • ketoconazole topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/​linagliptin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
  • hydrocortisone (systemic)
  • cetirizine (systemic)
  • Talimogene Laherparepvec
  • Diacerein
  • Magnesium glucoheptonate
  • acyclovir and hydrocortisone
  • acyclovir (ophthalmic)
  • acyclovir (topical)
  • docosanol cream
  • camphor and phenol
  • dolutegravir, abacavir, and lamivudine
  • peramivir
  • lisdexamfetamine
  • ergoloid mesylates
  • memantine/donepezil
  • tranylcypromine
  • isocarboxazid
  • methenamine/sodium salicylate/benzoic acid
  • mometasone topical (Rx)
  • Esketamine intranasal
  • Oracit
  • Shohls Solution
  • sodium lactate
  • sodium citrate
  • lecanemab
  • donepezil (Rx)
  • donepezil transdermal
  • sodium thiosulfate
  • ciclopirox
  • undecylenic acid
  • butenafine
  • calcium and vitamin D
  • zoledronic acid
  • calcitonin salmon
  • pizotifen
  • indoramin
  • salicylic acid acne
  • minoxidil topical
  • adapalene
  • orlistat
  • COVID-19 subunit vaccine
  • amoxicillin /vonoprazan
  • levamlodipine (Rx)
  • Omeprazole, amoxicillin, and clarithromycin
  • simvastatin/ezetimibe
  • amlodipine/atorvastatin
  • amoxicillin and clavulanate potassium
  • lansoprazole, amoxicillin, and clarithromycin
  • noradrenaline
  • carbaryl
  • botulinum toxin
  • atropine
  • artemether/lumefantrine
  • ergonovine
  • bunazosin (Not available in the United States)
  • ibalizumab
  • dolutegravir
  • hydrocodone/pseudoephedrine
  • cetirizine/pseudoephedrine
  • acetaminophen/dextromethorphan/pseudoephedrine/guaifenesin
  • acetaminophen IV/ibuprofen IV (Pending FDA Approval)
  • medroxyprogesterone
  • acetaminophen/caffeine
  • Acetaminophen/magnesium salicylate/pamabrom
  • megestrol
  • pyridoxine (vitamin B6)
  • folic acid-cyanocobalamin-pyridoxine
  • L-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
  • estropipate
  • betamethasone (systemic)
  • dolutegravir and lamivudine
  • zidovudine and lamivudine
  • mineral oil (oral/rectal)
  • regular insulin
  • dextromethorphan/bupropion
  • diphenhydramine/ibuprofen
  • enfuvirtide
  • doxapram
  • methamphetamine
  • dextroamphetamine
  • ephedrine
  • brompheniramine, dextromethorphan and phenylephrine
  • aspirin, chlorpheniramine, and phenylephrine
  • acetaminophen, pheniramine, and phenylephrine
  • chlorpheniramine and phenylephrine
  • guaifenesin and phenylephrine
  • rivastigmine
  • pyridostigmine
  • arecoline
  • physostigmine
  • abobotulinumtoxinA
  • echothiophate iodide
  • malathion
  • glibenclamide
  • rimabotulinumtoxinB
  • pioglitazone
  • daxibotulinumtoxinA
  • prabotulinumtoxinA
  • mepenzolate
  • trospium
  • modafinil
  • budesonide (oral inhalation)
  • budesonide (nasal)
  • budesonide (Topical)
  • vedolizumab
  • hydrocodone and homatropine
  • homatropine ophthalmic
  • methscopolamine
  • oxandrolone
  • nandrolone
  • fluoxymesterone
  • procyclidine
  • biperiden
  • benztropine
  • oxymetholone
  • ipratropium
  • belladonna/opium
  • pilocarpine
  • nicotine intranasal
  • succinylcholine
  • cromolyn sodium
  • mepolizumab
  • palivizumab
  • reslizumab
  • dupilumab
  • potassium iodide
  • beclomethasone (nasal)
  • tetrahydrozoline nasal
  • fluticasone (topical)
  • tecovirimat
  • entacapone
  • vaccinia immune globulin intravenous (Rx)
  • smallpox (vaccinia) vaccine, live
  • terazosin
  • labetalol 
  • smallpox and monkeypox vaccine (live, nonreplicating) (US: Availability limited to health department/CDC expanded access protocol) (Rx)
  • oxymetazoline
  • xylometazoline
  • meclizine
  • prazosin
  • belinostat
  • nabilone
  • tripelennamine
  • bismuth subcitrate, metronidazole and tetracycline
  • levalbuterol
  • rifaximin
  • cotrimoxazole
  • ethacrynic acid
  • senna
  • bisacodyl
  • sodium picosulfate, citric acid, and magnesium oxide
  • kaolin
  • anastrozole
  • docusate
  • cascara
  • dichlorphenamide
  • bismuth subsalicylate
  • methylcellulose
  • magnesium sulfate 
  • talazoparib
  • diphenoxylate/atropine
  • bacillus clausii
  • psyllium
  • bifidobacterium
  • lactobacillus
  • saccharomyces boulardii
  • lanreotide
  • cyproterone
  • ramucirumab (Rx)
  • fidaxomicin
  • tobramycin (systemic)
  • dacomitinib
  • pembrolizumab
  • amikacin (systemic)
  • panitumumab
  • blinatumomab
  • durvalumab
  • olaratumab
  • necitumumab
  • moxetumomab pasudotox
  • mogamulizumab
  • inotuzumab
  • dinutuximab
  • pentamycin
  • dibekacin
  • cemiplimab
  • gemtuzumab
  • demeclocycline
  • omadacycline
  • tobramycin (ophthalmic)
  • sarecycline
  • cefiderocol
  • valrubicin
  • plicamycin
  • denileukin diftitox
  • decitabine
  • niraparib
  • methacholine
  • carbachol
  • bethanechol
  • acetylcholine
  • atezolizumab
  • raloxifene
  • avelumab
  • leucovorin
  • cladabrine
  • pralatrexate
  • meclofenamate
  • pemetrexed
  • ustekinumab
  • diroximel fumarate
  • daratumumab
  • coccidioidin skin test
  • candida albicans extract
  • brewer’s yeast
  • poliovirus vaccine, live, trivalent
  • elotuzumab
  • trimetrexate
  • l-methyl folate
  • methyclothiazide
  • Influenza virus vaccine
  • acitretin
  • tafamidis
  • sapropterin
  • Pidotimod
  • nitisinone
  • mipomersen
  • levetiracetam
  • Inebilizumab
  • Diethylamine salicylate
  • COVID-19 vaccine
  • Cephalothin
  • alitretinoin
  • Alitretinoin
  • methotrexate
  • verteporfin
  • omacetaxine
  • methyl aminolevulinate topical
  • efgartigimod alfa
  • aminolevulinic acid
  • cetuximab
  • streptozocin
  • zoster vaccine recombinant
  • lyme disease vaccine
  • human papillomavirus vaccine
  • daclizumab
  • lomustiine
  • amitriptyline
  • triptorelin
  • Tedizolid
  • rituximab
  • darolutamide
  • altretamine
  • Varicella-zoster vaccine
  • topotecan
  • ajmaline
  • pneumococcal vaccine
  • poliovirus vaccine
  • adenovirus vaccine type 7
  • adenovirus vaccine type 4
  • brincidofovir
  • lenograstim
  • ofatumumab
  • doxorubicin
  • thioguanine
  • tetanus toxoid
  • primidone
  • lipegfilgrastim
  • pegaspargase
  • monomethyl fumarate
  • ibritumomab
  • dimethyl fumarate
  • varicella-zoster vaccine (recombinant)
  • influenza virus vaccine, h5n1, live
  • carmustine
  • influenza virus vaccine (h5n1), adjuvanted
  • influenza a (h5n1) vaccine
  • eluxadoline
  • influenza virus vaccine quadrivalent, adjuvanted
  • idecabtagene vicleucel
  • adenovirus types 4 and 7 live, oral
  • thiotepa
  • tocilizumab
  • levodopa inhaled
  • efalizumab
  • canakinumab
  • aminoglutethimide
  • ado-trastuzumab emtansine
  • adenovirus vaccine
  • zoster vaccine live
  • typhoid vaccine, live
  • influenza virus vaccine, live, trivalent
  • influenza virus vaccine, h1n1, live
  • delavirdine
  • paclitaxel
  • siltuximab
  • miconazole
  • fludarabine
  • epirubicin
  • vinblastine
  • lomustine
  • risankizumab
  • rilonacept
  • pacritinib
  • linezolid
  • griseofulvin
  • vincristine
  • rufinamide
  • phenobarbital
  • nelarabine
  • mitoxantrone
  • mitomycin
  • mitapivat
  • letermovir
  • lasmiditan
  • idarubicin
  • filgrastim
  • elagolix
  • daunorubicin
  • daclatasvir
  • carfilzomib
  • anakinra
  • alefacept
  • thalidomide
  • teriflunomide
  • rubella virus vaccine
  • ozanimod
  • mumps virus vaccine
  • measles virus vaccine
  • golimumab
  • etanercept
  • certolizumab
  • adalimumab
  • etoposide
  • mechlorethamine
  • adenovirus type 7 vaccine
  • melphalan
  • palifermin
  • pimecrolimus
  • ropeginterferon alfa 2b
  • tacrolimus
  • tofacitinib
  • amphotericin B cholesteryl sulfate
  • amphotericin B deoxycholate
  • amphotericin B liposomal
  • amphotericin B phospholipid complex
  • anthrax vaccine adsorbed
  • denosumab
  • diphtheria & tetanus toxoids
  • echinacea
  • haemophilus influenzae type b vaccine
  • hepatitis A vaccine inactivated
  • hepatitis a/b vaccine
  • hepatitis b vaccine
  • HIV vaccine
  • human papillomavirus vaccine, quadrivalent
  • hydroxyurea
  • influenza virus vaccine (H5N1)
  • influenza virus vaccine trivalent
  • influenza virus vaccine trivalent, adjuvanted
  • influenza virus vaccine trivalent, recombinant
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • meningococcal A C Y and W-135 polysaccharide vaccine combined
  • meningococcal group B vaccine
  • ofatumumab SC
  • pneumococcal vaccine 13-valent
  • pneumococcal vaccine heptavalent
  • pneumococcal vaccine polyvalent
  • poliovirus vaccine inactivated
  • rabies vaccine
  • sipuleucel-T
  • trastuzumab
  • trastuzumab deruxtecan
  • eslicarbazepine acetate
  • vitamin A
  • rifampin
  • belzutifan
  • belimumab
  • belatacept
  • armodafinil
  • amobarbital
  • alemtuzumab
  • ocrelizumab
  • nivolumab
  • natalizumab
  • fingolimod
  • desogestrel
  • butalbital
  • brexanolone
  • zoster vaccine
  • yellow fever vaccine
  • varicella virus vaccine
  • smallpox vaccine
  • rotavirus vaccine
  • rubella vaccine
  • influenza virus vaccine quadrivalent
  • atracurium
  • dengue vaccine
  • tisagenlecleucel
  • lisocabtagene maraleucel
  • ciltacabtagene autoleucel
  • brexucabtagene autoleucel
  • axicabtagene ciloleucel
  • chlorambucil
  • ethinyl estradiol
  • dicumarol
  • atenolol
  • anisindione
  • penicillin G benzathine
  • sequelerin
  • chloramphenicol
  • heparin
  • enoxaparin
  • dalteparin
  • bivalirudin
  • argatroban
  • willow bark
  • bazedoxifene/conjugated estrogens
  • aspirin rectal
  • aspirin/citric acid/sodium bicarbonate
  • aspirin
  • ganaxolone
  • erythromycin stearate
  • erythromycin lactobionate
  • erythromycin ethylsuccinate
  • elbasvir/grazoprevir
  • daridorexant
  • cholera vaccine
  • lumacaftor/ivacaftor
  • dienogest/estradiol valerate
  • zafirlukast
  • urofollitropin
  • tralokinumab
  • torsemide
  • tazarotene
  • pseudoephedrine
  • propoxiphene napsylate
  • propoxiphene hydrochloride
  • oxyphencyclimine hydrochloride
  • oxymetazoline hydrochloride
  • naxitamab
  • nandrolone decanoate
  • methylphenidate
  • methocarbamol
  • idoxuridine
  • hyaluronidase
  • hyaluronic acid
  • gonadoreline hydrochloride
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  • ganirelix acetate
  • gallium citrate
  • fulvestrant
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  • divalproex sodium
  • diclorfenamide
  • dezocine
  • desmopressin acetate
  • demeclocycline hydrochloride
  • defibrotide sodium
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  • darunavir
  • darifenacin hydrobromide
  • daptomycin
  • dapsone
  • dantrolene sodium
  • danazol
  • dalafampridine
  • dalbavancin Hydrochloride
  • daclatasvir dihydrochloride
  • dactinomycin
  • dacitabine
  • cefiderocol sulfate tosylate
  • butoconazole nitrate
  • benralizumab (Rx)
  • albuterol
  • acetylcysteine
  • acebutolol
  • acam2000
  • abrocitinib
  • abatacept
  • abametapir
  • abaloparatide
  • chloroquine
  • ferric maltol
  • lorlatinib
  • piracetam
  • timolol
  • chlorothiazide
  • ferric pyrophosphate citrate
  • lornoxicam
  • piretanide
  • tinidazole
  • chloroxylenol
  • ferric sulfate
  • lorpiprazole
  • pirfenidone
  • tiopronin
  • chlorpheniramine
  • ferrous bisglycinate
  • losartan
  • piroxicam
  • tiotropium
  • chlorpromazine
  • ferrous fumarate
  • lovastatin
  • pitavastatin
  • tipranavir
  • chlorpropamide
  • ferrous gluconate
  • loxoprofen
  • pitolisant
  • tirofiban
  • chlorprothixene
  • ferrous succinate
  • lubiprostone
  • pivampicillin
  • tisotumab vedotin
  • chlorthalidone
  • ferrous sulfate anhydrous
  • lumateperone
  • pivmecillinam
  • tixocortol
  • chlorzoxazone
  • ferumoxides
  • lumefantrine
  • plazomicin
  • tizanidine
  • abiraterone
  • cholecalciferolc
  • ferumoxsil
  • lumiracoxib
  • plerixafor
  • tobramycin (oral inhalation)
  • acalabrutinib
  • choline c 11
  • ferumoxytol
  • lurasidone
  • polatuzumab vedotin
  • tocainide
  • acarbose
  • choline magnesium trisalicylate
  • fesoterodine
  • lurbinectedin
  • polythiazide
  • tocofersolan
  • aceclofenac
  • choline salicylate
  • fexinidazole
  • lynestrenol
  • pomalidomide
  • tocopherol
  • acemetacin
  • chondroitin sulfate
  • finasteride
  • macimorelin
  • ponatinib
  • acenocoumarol
  • chromic chloride
  • finerenone (Rx)
  • macitentan
  • ponesimod
  • tolazamide
  • acetaminophen
  • chromic nitrate
  • fish oil
  • magaldrate
  • posaconazole
  • tolbutamide
  • acetazolamide
  • chromium
  • flavoxate
  • magnesium
  • potassium
  • tolcapone
  • acetohexamide
  • chromium gluconate
  • flecainide
  • magnesium carbonate
  • potassium acetate
  • tolfenamic acid
  • acetylsalicylic acid
  • chromium nicotinate
  • flibanserin
  • magnesium chloride
  • potassium bicarbonate
  • tolmetin
  • acipimox
  • chromous sulfate
  • floctafenine
  • magnesium citrate
  • potassium cation
  • tolterodine
  • aclidinium
  • ciclesonide
  • florbetaben (18f)
  • magnesium gluconate
  • potassium chloride
  • tolvaptan
  • acrivastine
  • cidofovir
  • florbetapir (18f)
  • magnesium hydroxide
  • potassium citrate
  • topiramate
  • acyclovir
  • cilazapril
  • floxuridine
  • magnesium oxide
  • potassium nitrate
  • adefovir dipivoxil
  • cilostazol
  • flucloxacillin
  • magnesium silicate
  • potassium perchlorate
  • torasemide
  • adenosine
  • cimetidine
  • fluconazole
  • potassium sulfate
  • toremifene
  • agomelatine
  • cinacalcet
  • flucytosine
  • magnesium trisilicate
  • tositumomab
  • albendazole
  • cinnarizine
  • fludeoxyglucose (18f)
  • mangafodipir
  • pralidoxime
  • trabectedin
  • albiglutide
  • cinoxacin
  • fludrocortisone
  • manidipine
  • pralsetinib
  • tramadol
  • albutrepenonacog alfa
  • ciprofibrate
  • fluindione
  • mannitol
  • pramipexole
  • trametinib
  • alclofenac
  • cisapride
  • flumazenil
  • maprotiline
  • pramlintide
  • trandolapril
  • aldesleukin
  • cisplatin
  • flumethasone
  • maraviroc
  • prasugrel
  • trastuzumab emtansine
  • alectinib
  • citalopram
  • flunarizine
  • maribavir
  • pravastatin
  • trazodone
  • alendronic acid
  • cladribine
  • flunisolide
  • mebeverine
  • prazepamb
  • treprostinil
  • alfentanil
  • clarithromycin
  • flunitrazepam
  • mecamylamine
  • praziquantel
  • tretinoin
  • alfuzosin
  • clemastine
  • fluocinolone acetonide
  • mecasermin
  • prednisolone
  • triamcinolone
  • alimemazine
  • clevidipine
  • fluocinonide
  • meclofenamic acid
  • prednisolone acetate
  • triamterene
  • aliskiren
  • clindamycin
  • fluocortolone
  • medrogestone
  • prednisolone phosphate
  • triazolam
  • allopurinol
  • clobazam
  • fluorouracil
  • medroxyprogesterone acetate
  • prednisone (Rx)
  • trichlormethiazide
  • almasilate
  • clobetasol propionate
  • fluoxetine
  • mefenamic acid
  • prednisone acetate
  • triclabendazole
  • almotriptan
  • clofarabine
  • flupentixol
  • mefloquine
  • pregabalin
  • triethylenetetramine
  • alogliptin
  • clofazimine
  • fluprednisolone
  • megestrol acetate
  • pregnenolone
  • trifluoperazine
  • alosetron
  • clofibrate
  • flurazepam
  • melatonin
  • prenylamine
  • trifluridine
  • alpelisib
  • clomipramine
  • flurbiprofen
  • meloxicam
  • pretomanid
  • trilaciclib
  • alprazolam
  • fluspirilene
  • memantine
  • primaquine
  • trilostane
  • clonidine
  • flutamide
  • menthyl salicylate
  • probenecid
  • trimebutine
  • aluminium phosphate
  • clopidogrel
  • fluticasone (nasal)
naproxen + 

apixaban

it may enhance the adverse/toxic effect of apixaban

almasilate

antacids decrease the systemic absorption of naproxen

aluminum hydroxide

antacids decrease the systemic absorption of naproxen

calcium carbonate

antacids decrease the systemic absorption of naproxen

magaldrate

antacids decrease the systemic absorption of naproxen

magnesium trisilicate

antacids decrease the systemic absorption of naproxen

almasilate

they decrease the absorption of naproxen

aluminum hydroxide

they decrease the absorption of naproxen

calcium carbonate

they decrease the absorption of naproxen

magaldrate

they decrease the absorption of naproxen

magnesium trisilicate

they decrease the absorption of naproxen

tanshinone I

may increase the toxic effect of non-steroidal anti-inflammatory drugs

rosmarinic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

caryophyllene

may increase the toxic effect of non-steroidal anti-inflammatory drugs

ursolic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

cepharanthine

may increase the toxic effect of non-steroidal anti-inflammatory drugs

pemetrexed

interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity

pralatrexate

interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity

diflunisal 

it increases the toxicity of naproxen

betaxolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

bisoprolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

metoprolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

nebivolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

sotalol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

betamethasone (systemic)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (oral inhalation)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (nasal)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (Topical)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

beclomethasone (nasal)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

etidronate

may increase the toxic effect of non-steroidal anti-inflammatory drugs

zoledronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

alendronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

ibandronate

may increase the toxic effect of non-steroidal anti-inflammatory drugs

pamidronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

chenodeoxycholic acid

may diminish the absorption of non-steroidal anti-inflammatory drugs

dicumarol

may increase the anti-platelet effect of anti-coagulants agents

heparin

may increase the anti-platelet effect of anti-coagulants agents

dalteparin

may increase the anti-platelet effect of anti-coagulants agents

dicoumarol

may increase the anti-platelet effect of anti-coagulants agents

idarucizumab

may increase the anti-platelet effect of anti-coagulants agents

eprosartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

irbesartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

losartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

olmesartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

telmisartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

tobramycin (systemic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

amikacin (systemic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

pentamycin

may decrease the excretion of non-steroidal anti-inflammatory drugs

dibekacin

may decrease the excretion of non-steroidal anti-inflammatory drugs

tobramycin (ophthalmic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

balsalazide

may increase the nephrotoxic effect of non-steroidal anti-inflammatory drugs

sulfasalazine

may increase the nephrotoxic effect of non-steroidal anti-inflammatory drugs

mistletoe 

anticoagulation is increased by dalteparin and decreased by mistletoe. The interaction's effect is unclear; exercise caution

Frequency defined:

1-10%

Constipation

Drowsiness

Heart burn

Edema

GI perforation

GI ulcers

Diarrhea

Diverticulitis

Hearing disturbances

Abdominal pain

Dizziness

Headache

Nausea

GI bleeding

Lightheadedness

Fluid retention

Stomatitis

Dyspnea

Black box warning

It is a non-steroidal anti-inflammatory drug (NSAID), carries a black box warning for an increased heart attack or stroke risk. This warning is the most severe from the U.S. Food and Drug Administration (FDA) and indicates that the drug may cause severe or life-threatening side effects.

Patients taking naproxen should talk to their healthcare provider about the potential risks and benefits of the medication and follow the recommended dosage and duration of use.

Contraindications

  • Hypersensitivity to naproxen or any other ingredient in the medication
  • Active peptic ulceration or a history of peptic ulceration
  • Hemophilia or other bleeding disorders
  • Severe heart failure or renal failure
  • The third trimester of pregnancy
  • Children under 12 years of age
  • Concomitant use of oral anticoagulants or other medications that increase the risk of bleeding

Caution

  • Gastrointestinal bleeding: It may increase the risk of gastrointestinal bleeding, especially in older adults or those with a history of ulcers or gastrointestinal bleeding.
  • Cardiovascular and cerebrovascular risks: Long-term use of naproxen may increase the risk of cardiovascular and cerebrovascular events.
  • Renal impairment: It should be used with caution in patients with renal impairment, as it may accumulate in the body and cause toxicity.
  • Hepatic impairment: It should be used cautiously in patients with hepatic impairment.
  • Anemia: It may cause anemia, particularly in patients who are already at risk for anemia, such as those with a history of bleeding or a deficiency in iron or vitamin B12.
  • Pregnancy and breastfeeding: It should be used during pregnancy and breastfeeding only if the potential benefits outweigh the potential risks.
  • Interactions with other medications: It may interact with other medications, including blood thinners, anti-platelet medications, and corticosteroids.

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the synthesis of prostaglandins in body tissues. Prostaglandins are chemicals that play a crucial role in inflammation, pain, and fever. Naproxen is an NSAID that works by inhibiting the activity of two enzymes, COX-1 and COX-2, which are responsible for the production of prostaglandins. By inhibiting the activity of these enzymes, Naproxen reduces the synthesis of prostaglandins and thereby reduces inflammation, pain, and fever. Naproxen may also have anti-inflammatory effects by inhibiting chemotaxis, altering lymphocyte activity, decreasing pro-inflammatory cytokine activity, and inhibiting neutrophil aggregation.

Pharmacodynamics

Inhibition of prostaglandin synthesis: It is a non-selective COX inhibitor, which inhibits the activity of both COX-1 and COX-2 enzymes. These enzymes are responsible for the production of prostaglandins, which play a crucial role in inflammation, pain, and fever. By inhibiting the activity of these enzymes, Naproxen reduces the synthesis of prostaglandins and thereby reduces inflammation, pain, and fever.

Anti-inflammatory effects: It has anti-inflammatory effects by inhibiting the activity of several mediators of inflammation, such as leukotrienes, and by reducing the production of pro-inflammatory cytokines.

Analgesic effects: It acts as an analgesic by reducing the synthesis of prostaglandins, which are involved in transmitting pain signals in the body.

Antipyretic effects: It has antipyretic effects by reducing the production of prostaglandins, which regulate body temperature.

Platelet inhibition: It has a weak anti-platelet effect by inhibiting the production of thromboxane A2, a prostaglandin involved in platelet aggregation.

Pharmacokinetics

Absorption

The absorption of the medication is 95% bioavailable, with an onset of 30-60 minutes and a duration of fewer than 12 hours. The peak serum time for tablets is 1-4 hours; for delayed release on an empty stomach, it is 2-12 hours, and for delayed release with food, it is 4-24 hours. The peak plasma concentration is 62-96 mcg/mL

Distribution

The drug is mostly protein bound at less than 99%. The volume of distribution is 0.16 L/kg.

Metabolism

It is metabolized in the liver via conjugation, with 6-Desmethylnaproxen and glucuronide conjugates as metabolites. The enzymes COX-1 and COX-2 are inhibited.

Elimination/excretion

The half-life is 12-17 hours and is not dialyzable. The clearance of the medication is 0.13 mL/min/kg, and it is excreted mainly in the urine (95%) and, to a lesser extent, in the feces (<3%)

Administration

It is typically administered orally in the form of tablets or capsules. The recommended dosage will vary depending on the treated condition and the individual’s response to the medication. It is usually taken every 8-12 hours with food to reduce the risk of stomach upset.

Patient information leaflet

Generic Name: naproxen

Pronounced: [ na-PROX-en ]

Why do we use naproxen?

It is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is used to treat a wide range of conditions, including:

  • Osteoarthritis and rheumatoid arthritis
  • Ankylosing spondylitis
  • Tendinitis and bursitis
  • Gout
  • Menstrual cramps
  • Acute pain, such as that caused by a toothache or injury
  • Migraine and other types of headaches

ADVERTISEMENT 

naproxen

Brand Name :

Anaprox, Naprosyn, Naproxen EC, Aleve, EC Naprosyn, naprox sodium

Synonyms :

Naprolag, naproxen, naproxeno

Class :

Non-steroidal anti-inflammatory drugs




No data available for drug.

Dosage Forms & Strengths

Tablet

220mg

250mg

275mg

375mg

500mg

550mg

Delayed release tablets

375mg

500mg

Extended-release tablets

375mg

500mg

750mg

Oral suspension

25mg/ml

Capsule

220mg

Dosage Forms & Strengths

Tablet

220mg

250mg

275mg

375mg

500mg

550mg

Delayed release tablets

375mg

500mg

Extended-release tablets

375mg

500mg

750mg

Oral suspension

25mg/ml

Capsule

220mg

Refer adult dosing

DRUG INTERACTION

naproxen

&

  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • rabies immune globulin, human (RIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone (Pending FDA Approval)
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid (Pending FDA Approval)
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitnib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • ketoconazole topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/​linagliptin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
  • hydrocortisone (systemic)
  • cetirizine (systemic)
  • Talimogene Laherparepvec
  • Diacerein
  • Magnesium glucoheptonate
  • acyclovir and hydrocortisone
  • acyclovir (ophthalmic)
  • acyclovir (topical)
  • docosanol cream
  • camphor and phenol
  • dolutegravir, abacavir, and lamivudine
  • peramivir
  • lisdexamfetamine
  • ergoloid mesylates
  • memantine/donepezil
  • tranylcypromine
  • isocarboxazid
  • methenamine/sodium salicylate/benzoic acid
  • mometasone topical (Rx)
  • Esketamine intranasal
  • Oracit
  • Shohls Solution
  • sodium lactate
  • sodium citrate
  • lecanemab
  • donepezil (Rx)
  • donepezil transdermal
  • sodium thiosulfate
  • ciclopirox
  • undecylenic acid
  • butenafine
  • calcium and vitamin D
  • zoledronic acid
  • calcitonin salmon
  • pizotifen
  • indoramin
  • salicylic acid acne
  • minoxidil topical
  • adapalene
  • orlistat
  • COVID-19 subunit vaccine
  • amoxicillin /vonoprazan
  • levamlodipine (Rx)
  • Omeprazole, amoxicillin, and clarithromycin
  • simvastatin/ezetimibe
  • amlodipine/atorvastatin
  • amoxicillin and clavulanate potassium
  • lansoprazole, amoxicillin, and clarithromycin
  • noradrenaline
  • carbaryl
  • botulinum toxin
  • atropine
  • artemether/lumefantrine
  • ergonovine
  • bunazosin (Not available in the United States)
  • ibalizumab
  • dolutegravir
  • hydrocodone/pseudoephedrine
  • cetirizine/pseudoephedrine
  • acetaminophen/dextromethorphan/pseudoephedrine/guaifenesin
  • acetaminophen IV/ibuprofen IV (Pending FDA Approval)
  • medroxyprogesterone
  • acetaminophen/caffeine
  • Acetaminophen/magnesium salicylate/pamabrom
  • megestrol
  • pyridoxine (vitamin B6)
  • folic acid-cyanocobalamin-pyridoxine
  • L-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
  • estropipate
  • betamethasone (systemic)
  • dolutegravir and lamivudine
  • zidovudine and lamivudine
  • mineral oil (oral/rectal)
  • regular insulin
  • dextromethorphan/bupropion
  • diphenhydramine/ibuprofen
  • enfuvirtide
  • doxapram
  • methamphetamine
  • dextroamphetamine
  • ephedrine
  • brompheniramine, dextromethorphan and phenylephrine
  • aspirin, chlorpheniramine, and phenylephrine
  • acetaminophen, pheniramine, and phenylephrine
  • chlorpheniramine and phenylephrine
  • guaifenesin and phenylephrine
  • rivastigmine
  • pyridostigmine
  • arecoline
  • physostigmine
  • abobotulinumtoxinA
  • echothiophate iodide
  • malathion
  • glibenclamide
  • rimabotulinumtoxinB
  • pioglitazone
  • daxibotulinumtoxinA
  • prabotulinumtoxinA
  • mepenzolate
  • trospium
  • modafinil
  • budesonide (oral inhalation)
  • budesonide (nasal)
  • budesonide (Topical)
  • vedolizumab
  • hydrocodone and homatropine
  • homatropine ophthalmic
  • methscopolamine
  • oxandrolone
  • nandrolone
  • fluoxymesterone
  • procyclidine
  • biperiden
  • benztropine
  • oxymetholone
  • ipratropium
  • belladonna/opium
  • pilocarpine
  • nicotine intranasal
  • succinylcholine
  • cromolyn sodium
  • mepolizumab
  • palivizumab
  • reslizumab
  • dupilumab
  • potassium iodide
  • beclomethasone (nasal)
  • tetrahydrozoline nasal
  • fluticasone (topical)
  • tecovirimat
  • entacapone
  • vaccinia immune globulin intravenous (Rx)
  • smallpox (vaccinia) vaccine, live
  • terazosin
  • labetalol 
  • smallpox and monkeypox vaccine (live, nonreplicating) (US: Availability limited to health department/CDC expanded access protocol) (Rx)
  • oxymetazoline
  • xylometazoline
  • meclizine
  • prazosin
  • belinostat
  • nabilone
  • tripelennamine
  • bismuth subcitrate, metronidazole and tetracycline
  • levalbuterol
  • rifaximin
  • cotrimoxazole
  • ethacrynic acid
  • senna
  • bisacodyl
  • sodium picosulfate, citric acid, and magnesium oxide
  • kaolin
  • anastrozole
  • docusate
  • cascara
  • dichlorphenamide
  • bismuth subsalicylate
  • methylcellulose
  • magnesium sulfate 
  • talazoparib
  • diphenoxylate/atropine
  • bacillus clausii
  • psyllium
  • bifidobacterium
  • lactobacillus
  • saccharomyces boulardii
  • lanreotide
  • cyproterone
  • ramucirumab (Rx)
  • fidaxomicin
  • tobramycin (systemic)
  • dacomitinib
  • pembrolizumab
  • amikacin (systemic)
  • panitumumab
  • blinatumomab
  • durvalumab
  • olaratumab
  • necitumumab
  • moxetumomab pasudotox
  • mogamulizumab
  • inotuzumab
  • dinutuximab
  • pentamycin
  • dibekacin
  • cemiplimab
  • gemtuzumab
  • demeclocycline
  • omadacycline
  • tobramycin (ophthalmic)
  • sarecycline
  • cefiderocol
  • valrubicin
  • plicamycin
  • denileukin diftitox
  • decitabine
  • niraparib
  • methacholine
  • carbachol
  • bethanechol
  • acetylcholine
  • atezolizumab
  • raloxifene
  • avelumab
  • leucovorin
  • cladabrine
  • pralatrexate
  • meclofenamate
  • pemetrexed
  • ustekinumab
  • diroximel fumarate
  • daratumumab
  • coccidioidin skin test
  • candida albicans extract
  • brewer’s yeast
  • poliovirus vaccine, live, trivalent
  • elotuzumab
  • trimetrexate
  • l-methyl folate
  • methyclothiazide
  • Influenza virus vaccine
  • acitretin
  • tafamidis
  • sapropterin
  • Pidotimod
  • nitisinone
  • mipomersen
  • levetiracetam
  • Inebilizumab
  • Diethylamine salicylate
  • COVID-19 vaccine
  • Cephalothin
  • alitretinoin
  • Alitretinoin
  • methotrexate
  • verteporfin
  • omacetaxine
  • methyl aminolevulinate topical
  • efgartigimod alfa
  • aminolevulinic acid
  • cetuximab
  • streptozocin
  • zoster vaccine recombinant
  • lyme disease vaccine
  • human papillomavirus vaccine
  • daclizumab
  • lomustiine
  • amitriptyline
  • triptorelin
  • Tedizolid
  • rituximab
  • darolutamide
  • altretamine
  • Varicella-zoster vaccine
  • topotecan
  • ajmaline
  • pneumococcal vaccine
  • poliovirus vaccine
  • adenovirus vaccine type 7
  • adenovirus vaccine type 4
  • brincidofovir
  • lenograstim
  • ofatumumab
  • doxorubicin
  • thioguanine
  • tetanus toxoid
  • primidone
  • lipegfilgrastim
  • pegaspargase
  • monomethyl fumarate
  • ibritumomab
  • dimethyl fumarate
  • varicella-zoster vaccine (recombinant)
  • influenza virus vaccine, h5n1, live
  • carmustine
  • influenza virus vaccine (h5n1), adjuvanted
  • influenza a (h5n1) vaccine
  • eluxadoline
  • influenza virus vaccine quadrivalent, adjuvanted
  • idecabtagene vicleucel
  • adenovirus types 4 and 7 live, oral
  • thiotepa
  • tocilizumab
  • levodopa inhaled
  • efalizumab
  • canakinumab
  • aminoglutethimide
  • ado-trastuzumab emtansine
  • adenovirus vaccine
  • zoster vaccine live
  • typhoid vaccine, live
  • influenza virus vaccine, live, trivalent
  • influenza virus vaccine, h1n1, live
  • delavirdine
  • paclitaxel
  • siltuximab
  • miconazole
  • fludarabine
  • epirubicin
  • vinblastine
  • lomustine
  • risankizumab
  • rilonacept
  • pacritinib
  • linezolid
  • griseofulvin
  • vincristine
  • rufinamide
  • phenobarbital
  • nelarabine
  • mitoxantrone
  • mitomycin
  • mitapivat
  • letermovir
  • lasmiditan
  • idarubicin
  • filgrastim
  • elagolix
  • daunorubicin
  • daclatasvir
  • carfilzomib
  • anakinra
  • alefacept
  • thalidomide
  • teriflunomide
  • rubella virus vaccine
  • ozanimod
  • mumps virus vaccine
  • measles virus vaccine
  • golimumab
  • etanercept
  • certolizumab
  • adalimumab
  • etoposide
  • mechlorethamine
  • adenovirus type 7 vaccine
  • melphalan
  • palifermin
  • pimecrolimus
  • ropeginterferon alfa 2b
  • tacrolimus
  • tofacitinib
  • amphotericin B cholesteryl sulfate
  • amphotericin B deoxycholate
  • amphotericin B liposomal
  • amphotericin B phospholipid complex
  • anthrax vaccine adsorbed
  • denosumab
  • diphtheria & tetanus toxoids
  • echinacea
  • haemophilus influenzae type b vaccine
  • hepatitis A vaccine inactivated
  • hepatitis a/b vaccine
  • hepatitis b vaccine
  • HIV vaccine
  • human papillomavirus vaccine, quadrivalent
  • hydroxyurea
  • influenza virus vaccine (H5N1)
  • influenza virus vaccine trivalent
  • influenza virus vaccine trivalent, adjuvanted
  • influenza virus vaccine trivalent, recombinant
  • meningococcal A C Y and W-135 diphtheria conjugate vaccine
  • meningococcal A C Y and W-135 polysaccharide vaccine combined
  • meningococcal group B vaccine
  • ofatumumab SC
  • pneumococcal vaccine 13-valent
  • pneumococcal vaccine heptavalent
  • pneumococcal vaccine polyvalent
  • poliovirus vaccine inactivated
  • rabies vaccine
  • sipuleucel-T
  • trastuzumab
  • trastuzumab deruxtecan
  • eslicarbazepine acetate
  • vitamin A
  • rifampin
  • belzutifan
  • belimumab
  • belatacept
  • armodafinil
  • amobarbital
  • alemtuzumab
  • ocrelizumab
  • nivolumab
  • natalizumab
  • fingolimod
  • desogestrel
  • butalbital
  • brexanolone
  • zoster vaccine
  • yellow fever vaccine
  • varicella virus vaccine
  • smallpox vaccine
  • rotavirus vaccine
  • rubella vaccine
  • influenza virus vaccine quadrivalent
  • atracurium
  • dengue vaccine
  • tisagenlecleucel
  • lisocabtagene maraleucel
  • ciltacabtagene autoleucel
  • brexucabtagene autoleucel
  • axicabtagene ciloleucel
  • chlorambucil
  • ethinyl estradiol
  • dicumarol
  • atenolol
  • anisindione
  • penicillin G benzathine
  • sequelerin
  • chloramphenicol
  • heparin
  • enoxaparin
  • dalteparin
  • bivalirudin
  • argatroban
  • willow bark
  • bazedoxifene/conjugated estrogens
  • aspirin rectal
  • aspirin/citric acid/sodium bicarbonate
  • aspirin
  • ganaxolone
  • erythromycin stearate
  • erythromycin lactobionate
  • erythromycin ethylsuccinate
  • elbasvir/grazoprevir
  • daridorexant
  • cholera vaccine
  • lumacaftor/ivacaftor
  • dienogest/estradiol valerate
  • zafirlukast
  • urofollitropin
  • tralokinumab
  • torsemide
  • tazarotene
  • pseudoephedrine
  • propoxiphene napsylate
  • propoxiphene hydrochloride
  • oxyphencyclimine hydrochloride
  • oxymetazoline hydrochloride
  • naxitamab
  • nandrolone decanoate
  • methylphenidate
  • methocarbamol
  • idoxuridine
  • hyaluronidase
  • hyaluronic acid
  • gonadoreline hydrochloride
  • glycopyrrolate
  • ganirelix acetate
  • gallium citrate
  • fulvestrant
  • fexofenadine hydrochloride
  • fenefluramine hydrochloride
  • febuxostat
  • famciclovir
  • ergocalciferol
  • divalproex sodium
  • diclorfenamide
  • dezocine
  • desmopressin acetate
  • demeclocycline hydrochloride
  • defibrotide sodium
  • deferiprone
  • deferasirox
  • daunorubicin hydrochloride
  • darunavir
  • darifenacin hydrobromide
  • daptomycin
  • dapsone
  • dantrolene sodium
  • danazol
  • dalafampridine
  • dalbavancin Hydrochloride
  • daclatasvir dihydrochloride
  • dactinomycin
  • dacitabine
  • cefiderocol sulfate tosylate
  • butoconazole nitrate
  • benralizumab (Rx)
  • albuterol
  • acetylcysteine
  • acebutolol
  • acam2000
  • abrocitinib
  • abatacept
  • abametapir
  • abaloparatide
  • chloroquine
  • ferric maltol
  • lorlatinib
  • piracetam
  • timolol
  • chlorothiazide
  • ferric pyrophosphate citrate
  • lornoxicam
  • piretanide
  • tinidazole
  • chloroxylenol
  • ferric sulfate
  • lorpiprazole
  • pirfenidone
  • tiopronin
  • chlorpheniramine
  • ferrous bisglycinate
  • losartan
  • piroxicam
  • tiotropium
  • chlorpromazine
  • ferrous fumarate
  • lovastatin
  • pitavastatin
  • tipranavir
  • chlorpropamide
  • ferrous gluconate
  • loxoprofen
  • pitolisant
  • tirofiban
  • chlorprothixene
  • ferrous succinate
  • lubiprostone
  • pivampicillin
  • tisotumab vedotin
  • chlorthalidone
  • ferrous sulfate anhydrous
  • lumateperone
  • pivmecillinam
  • tixocortol
  • chlorzoxazone
  • ferumoxides
  • lumefantrine
  • plazomicin
  • tizanidine
  • abiraterone
  • cholecalciferolc
  • ferumoxsil
  • lumiracoxib
  • plerixafor
  • tobramycin (oral inhalation)
  • acalabrutinib
  • choline c 11
  • ferumoxytol
  • lurasidone
  • polatuzumab vedotin
  • tocainide
  • acarbose
  • choline magnesium trisalicylate
  • fesoterodine
  • lurbinectedin
  • polythiazide
  • tocofersolan
  • aceclofenac
  • choline salicylate
  • fexinidazole
  • lynestrenol
  • pomalidomide
  • tocopherol
  • acemetacin
  • chondroitin sulfate
  • finasteride
  • macimorelin
  • ponatinib
  • acenocoumarol
  • chromic chloride
  • finerenone (Rx)
  • macitentan
  • ponesimod
  • tolazamide
  • acetaminophen
  • chromic nitrate
  • fish oil
  • magaldrate
  • posaconazole
  • tolbutamide
  • acetazolamide
  • chromium
  • flavoxate
  • magnesium
  • potassium
  • tolcapone
  • acetohexamide
  • chromium gluconate
  • flecainide
  • magnesium carbonate
  • potassium acetate
  • tolfenamic acid
  • acetylsalicylic acid
  • chromium nicotinate
  • flibanserin
  • magnesium chloride
  • potassium bicarbonate
  • tolmetin
  • acipimox
  • chromous sulfate
  • floctafenine
  • magnesium citrate
  • potassium cation
  • tolterodine
  • aclidinium
  • ciclesonide
  • florbetaben (18f)
  • magnesium gluconate
  • potassium chloride
  • tolvaptan
  • acrivastine
  • cidofovir
  • florbetapir (18f)
  • magnesium hydroxide
  • potassium citrate
  • topiramate
  • acyclovir
  • cilazapril
  • floxuridine
  • magnesium oxide
  • potassium nitrate
  • adefovir dipivoxil
  • cilostazol
  • flucloxacillin
  • magnesium silicate
  • potassium perchlorate
  • torasemide
  • adenosine
  • cimetidine
  • fluconazole
  • potassium sulfate
  • toremifene
  • agomelatine
  • cinacalcet
  • flucytosine
  • magnesium trisilicate
  • tositumomab
  • albendazole
  • cinnarizine
  • fludeoxyglucose (18f)
  • mangafodipir
  • pralidoxime
  • trabectedin
  • albiglutide
  • cinoxacin
  • fludrocortisone
  • manidipine
  • pralsetinib
  • tramadol
  • albutrepenonacog alfa
  • ciprofibrate
  • fluindione
  • mannitol
  • pramipexole
  • trametinib
  • alclofenac
  • cisapride
  • flumazenil
  • maprotiline
  • pramlintide
  • trandolapril
  • aldesleukin
  • cisplatin
  • flumethasone
  • maraviroc
  • prasugrel
  • trastuzumab emtansine
  • alectinib
  • citalopram
  • flunarizine
  • maribavir
  • pravastatin
  • trazodone
  • alendronic acid
  • cladribine
  • flunisolide
  • mebeverine
  • prazepamb
  • treprostinil
  • alfentanil
  • clarithromycin
  • flunitrazepam
  • mecamylamine
  • praziquantel
  • tretinoin
  • alfuzosin
  • clemastine
  • fluocinolone acetonide
  • mecasermin
  • prednisolone
  • triamcinolone
  • alimemazine
  • clevidipine
  • fluocinonide
  • meclofenamic acid
  • prednisolone acetate
  • triamterene
  • aliskiren
  • clindamycin
  • fluocortolone
  • medrogestone
  • prednisolone phosphate
  • triazolam
  • allopurinol
  • clobazam
  • fluorouracil
  • medroxyprogesterone acetate
  • prednisone (Rx)
  • trichlormethiazide
  • almasilate
  • clobetasol propionate
  • fluoxetine
  • mefenamic acid
  • prednisone acetate
  • triclabendazole
  • almotriptan
  • clofarabine
  • flupentixol
  • mefloquine
  • pregabalin
  • triethylenetetramine
  • alogliptin
  • clofazimine
  • fluprednisolone
  • megestrol acetate
  • pregnenolone
  • trifluoperazine
  • alosetron
  • clofibrate
  • flurazepam
  • melatonin
  • prenylamine
  • trifluridine
  • alpelisib
  • clomipramine
  • flurbiprofen
  • meloxicam
  • pretomanid
  • trilaciclib
  • alprazolam
  • fluspirilene
  • memantine
  • primaquine
  • trilostane
  • clonidine
  • flutamide
  • menthyl salicylate
  • probenecid
  • trimebutine
  • aluminium phosphate
  • clopidogrel
  • fluticasone (nasal)
naproxen + 

apixaban

it may enhance the adverse/toxic effect of apixaban

almasilate

antacids decrease the systemic absorption of naproxen

aluminum hydroxide

antacids decrease the systemic absorption of naproxen

calcium carbonate

antacids decrease the systemic absorption of naproxen

magaldrate

antacids decrease the systemic absorption of naproxen

magnesium trisilicate

antacids decrease the systemic absorption of naproxen

almasilate

they decrease the absorption of naproxen

aluminum hydroxide

they decrease the absorption of naproxen

calcium carbonate

they decrease the absorption of naproxen

magaldrate

they decrease the absorption of naproxen

magnesium trisilicate

they decrease the absorption of naproxen

tanshinone I

may increase the toxic effect of non-steroidal anti-inflammatory drugs

rosmarinic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

caryophyllene

may increase the toxic effect of non-steroidal anti-inflammatory drugs

ursolic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

cepharanthine

may increase the toxic effect of non-steroidal anti-inflammatory drugs

pemetrexed

interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity

pralatrexate

interaction with NSAIDs may lead to increased toxicity such as myelosuppression, renal toxicity, and GI toxicity

diflunisal 

it increases the toxicity of naproxen

betaxolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

bisoprolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

metoprolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

nebivolol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

sotalol

NSAIDs may diminish the antihypertensive effect of Beta-Blockers

betamethasone (systemic)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (oral inhalation)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (nasal)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

budesonide (Topical)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

beclomethasone (nasal)

may increase the toxic effect of non-steroidal anti-inflammatory drugs

etidronate

may increase the toxic effect of non-steroidal anti-inflammatory drugs

zoledronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

alendronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

ibandronate

may increase the toxic effect of non-steroidal anti-inflammatory drugs

pamidronic acid

may increase the toxic effect of non-steroidal anti-inflammatory drugs

chenodeoxycholic acid

may diminish the absorption of non-steroidal anti-inflammatory drugs

dicumarol

may increase the anti-platelet effect of anti-coagulants agents

heparin

may increase the anti-platelet effect of anti-coagulants agents

dalteparin

may increase the anti-platelet effect of anti-coagulants agents

dicoumarol

may increase the anti-platelet effect of anti-coagulants agents

idarucizumab

may increase the anti-platelet effect of anti-coagulants agents

eprosartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

irbesartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

losartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

olmesartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

telmisartan

may increase the toxic effect of non-steroidal anti-inflammatory drugs

tobramycin (systemic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

amikacin (systemic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

pentamycin

may decrease the excretion of non-steroidal anti-inflammatory drugs

dibekacin

may decrease the excretion of non-steroidal anti-inflammatory drugs

tobramycin (ophthalmic)

may decrease the excretion of non-steroidal anti-inflammatory drugs

balsalazide

may increase the nephrotoxic effect of non-steroidal anti-inflammatory drugs

sulfasalazine

may increase the nephrotoxic effect of non-steroidal anti-inflammatory drugs

mistletoe 

anticoagulation is increased by dalteparin and decreased by mistletoe. The interaction's effect is unclear; exercise caution

Mechanism of action

It is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins, chemicals in the body that cause inflammation and pain. Its action inhibits cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By inhibiting these enzymes, naproxen reduces the production of prostaglandins and thus reduces inflammation and pain

Spectrum

The spectrum of naproxen activity includes treating pain, inflammation, and fever. It is commonly used to treat rheumatoid arthritis, osteoarthritis, gout, and menstrual cramps. It can also alleviate pain caused by injuries, such as sprains and strains, and reduce fever

Frequency defined:

1-10%

Constipation

Drowsiness

Heart burn

Edema

GI perforation

GI ulcers

Diarrhea

Diverticulitis

Hearing disturbances

Abdominal pain

Dizziness

Headache

Nausea

GI bleeding

Lightheadedness

Fluid retention

Stomatitis

Dyspnea

Black box warning

It is a non-steroidal anti-inflammatory drug (NSAID), carries a black box warning for an increased heart attack or stroke risk. This warning is the most severe from the U.S. Food and Drug Administration (FDA) and indicates that the drug may cause severe or life-threatening side effects.

Patients taking naproxen should talk to their healthcare provider about the potential risks and benefits of the medication and follow the recommended dosage and duration of use.

Contraindications

  • Hypersensitivity to naproxen or any other ingredient in the medication
  • Active peptic ulceration or a history of peptic ulceration
  • Hemophilia or other bleeding disorders
  • Severe heart failure or renal failure
  • The third trimester of pregnancy
  • Children under 12 years of age
  • Concomitant use of oral anticoagulants or other medications that increase the risk of bleeding

Caution

  • Gastrointestinal bleeding: It may increase the risk of gastrointestinal bleeding, especially in older adults or those with a history of ulcers or gastrointestinal bleeding.
  • Cardiovascular and cerebrovascular risks: Long-term use of naproxen may increase the risk of cardiovascular and cerebrovascular events.
  • Renal impairment: It should be used with caution in patients with renal impairment, as it may accumulate in the body and cause toxicity.
  • Hepatic impairment: It should be used cautiously in patients with hepatic impairment.
  • Anemia: It may cause anemia, particularly in patients who are already at risk for anemia, such as those with a history of bleeding or a deficiency in iron or vitamin B12.
  • Pregnancy and breastfeeding: It should be used during pregnancy and breastfeeding only if the potential benefits outweigh the potential risks.
  • Interactions with other medications: It may interact with other medications, including blood thinners, anti-platelet medications, and corticosteroids.

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

It is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the synthesis of prostaglandins in body tissues. Prostaglandins are chemicals that play a crucial role in inflammation, pain, and fever. Naproxen is an NSAID that works by inhibiting the activity of two enzymes, COX-1 and COX-2, which are responsible for the production of prostaglandins. By inhibiting the activity of these enzymes, Naproxen reduces the synthesis of prostaglandins and thereby reduces inflammation, pain, and fever. Naproxen may also have anti-inflammatory effects by inhibiting chemotaxis, altering lymphocyte activity, decreasing pro-inflammatory cytokine activity, and inhibiting neutrophil aggregation.

Pharmacodynamics

Inhibition of prostaglandin synthesis: It is a non-selective COX inhibitor, which inhibits the activity of both COX-1 and COX-2 enzymes. These enzymes are responsible for the production of prostaglandins, which play a crucial role in inflammation, pain, and fever. By inhibiting the activity of these enzymes, Naproxen reduces the synthesis of prostaglandins and thereby reduces inflammation, pain, and fever.

Anti-inflammatory effects: It has anti-inflammatory effects by inhibiting the activity of several mediators of inflammation, such as leukotrienes, and by reducing the production of pro-inflammatory cytokines.

Analgesic effects: It acts as an analgesic by reducing the synthesis of prostaglandins, which are involved in transmitting pain signals in the body.

Antipyretic effects: It has antipyretic effects by reducing the production of prostaglandins, which regulate body temperature.

Platelet inhibition: It has a weak anti-platelet effect by inhibiting the production of thromboxane A2, a prostaglandin involved in platelet aggregation.

Pharmacokinetics

Absorption

The absorption of the medication is 95% bioavailable, with an onset of 30-60 minutes and a duration of fewer than 12 hours. The peak serum time for tablets is 1-4 hours; for delayed release on an empty stomach, it is 2-12 hours, and for delayed release with food, it is 4-24 hours. The peak plasma concentration is 62-96 mcg/mL

Distribution

The drug is mostly protein bound at less than 99%. The volume of distribution is 0.16 L/kg.

Metabolism

It is metabolized in the liver via conjugation, with 6-Desmethylnaproxen and glucuronide conjugates as metabolites. The enzymes COX-1 and COX-2 are inhibited.

Elimination/excretion

The half-life is 12-17 hours and is not dialyzable. The clearance of the medication is 0.13 mL/min/kg, and it is excreted mainly in the urine (95%) and, to a lesser extent, in the feces (<3%)

Administration

It is typically administered orally in the form of tablets or capsules. The recommended dosage will vary depending on the treated condition and the individual’s response to the medication. It is usually taken every 8-12 hours with food to reduce the risk of stomach upset.

Patient information leaflet

Generic Name: naproxen

Pronounced: [ na-PROX-en ]

Why do we use naproxen?

It is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is used to treat a wide range of conditions, including:

  • Osteoarthritis and rheumatoid arthritis
  • Ankylosing spondylitis
  • Tendinitis and bursitis
  • Gout
  • Menstrual cramps
  • Acute pain, such as that caused by a toothache or injury
  • Migraine and other types of headaches

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