Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
No Data Available.
Synonyms :
nefopam
Class :
Analgesics (Non-Opioid) and Antipyretics
Brand Name :
No Data Available.
Synonyms :
nefopam
Class :
Analgesics (Non-Opioid) and Antipyretics
Dosage Forms & Strengths
Tablet
30 mg
for ≥12 years old:
Take a dose of 60 mg orally three times a day
Refer to adult dosing
Actions and Spectrum
nefopam inhibits the reuptake of serotonin at the synapses between nerve cells. By increasing serotonin levels, it might influence pain perception and mood. nefopam also modulate the activity which are involved in the transmission of pain signals in the central nervous system.
Frequency not defined
Palpitations
Nausea
Sympathomimetic effects
Diarrhea
Abdominal pain
Vomiting
Anticholinergic effects
Headache
Hypotension
Syncope
Paraesthesia
Tremor
Hallucination
Diaphoresis
Convulsion
Lightheadedness
Angioedema
Allergic reactions
Insomnia
Nervousness
Confusion
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
nefopam inhibits the reuptake of serotonin, a neurotransmitter associated with pain modulation and mood regulation at nerve synapses.
This action may contribute to its analgesic and potential antidepressant effects.
Pharmacodynamics
nefopam can modulate dopamine receptors, influencing the release and reuptake of dopamine.
The interaction with the dopaminergic system is involved in its analgesic and potential psychoactive effects.
Pharmacokinetics
Absorption
nefopam is rapidly absorbed from the gastrointestinal tract.
Distribution
nefopam is distributed throughout the body.
Metabolism
nefopam undergoes extensive metabolism primarily in the liver.
Elimination and excretion
The elimination of nefopam occurs through the urine.
Administration
nefopam is available in tablet form for oral administration.
Patient information leaflet
Generic Name: nefopam
Why do we use nefopam?
nefopam is used for the management of moderate to severe pain. nefopam can be used to treat acute pain associated with medical conditions such as kidney stones, pancreatitis, and certain musculoskeletal conditions.
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