nefopam

Action and Spectrum

Actions and Spectrum 

nefopam inhibits the reuptake of serotonin at the synapses between nerve cells. By increasing serotonin levels, it might influence pain perception and mood. nefopam also modulate the activity which are involved in the transmission of pain signals in the central nervous system.

Drug Interaction

Adverse Reaction

Frequency not defined  

Palpitations 

Nausea 

Sympathomimetic effects  

Diarrhea  

Abdominal pain 

Vomiting 

Anticholinergic effects  

Headache 

Hypotension  

Syncope  

Paraesthesia  

Tremor 

Hallucination  

Diaphoresis 

Convulsion  

Lightheadedness  

Angioedema 

Allergic reactions  

Insomnia 

Nervousness 

Confusion 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• nefopam is contraindicated in individuals who have a known hypersensitivity or allergy to the drug or any of its components. 

Caution: 

• Individuals with mild to moderate renal impairment should use nefopam with caution.  
• Individuals with pre-existing cardiovascular conditions should use nefopam cautiously. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

nefopam inhibits the reuptake of serotonin, a neurotransmitter associated with pain modulation and mood regulation at nerve synapses.  

This action may contribute to its analgesic and potential antidepressant effects. 

Pharmacodynamics 

nefopam can modulate dopamine receptors, influencing the release and reuptake of dopamine.  

The interaction with the dopaminergic system is involved in its analgesic and potential psychoactive effects. 

Pharmacokinetics 

Absorption   

nefopam is rapidly absorbed from the gastrointestinal tract. 

Distribution 

nefopam is distributed throughout the body. 

Metabolism 

nefopam undergoes extensive metabolism primarily in the liver.  

Elimination and excretion 

The elimination of nefopam occurs through the urine.

Adminstartion

Administration 

nefopam is available in tablet form for oral administration.

Patient Information Leaflet

Patient information leaflet 

Generic Name: nefopam 

Why do we use nefopam? 

nefopam is used for the management of moderate to severe pain. nefopam can be used to treat acute pain associated with medical conditions such as kidney stones, pancreatitis, and certain musculoskeletal conditions.