Don’t Ignore Your Kidneys: Early Action Can Slow CKD
January 19, 2026
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
N/A
Synonyms :
neladenoson
Class :
Cardiovascular agents
Brand Name :
N/A
Synonyms :
neladenoson
Class :
Cardiovascular agents
Dosage Forms & Strengths
Congestive Heart Failure (CHF)
5 to 40 mg is given orally once a day for 5 months
Safety and efficacy not determined.
Refer to the adult dosing regimen
Actions and spectrum:
It belongs to the class of selective adenosine A2A receptor agonist.
Neladenoson works by enhancing the natural sleep-inducing effects of adenosine which stimulates its physiological action in the brain.
Frequency not defined
Drowsiness
Constipation
Abdominal discomfort
Diarrhea
Headache
Dizziness
Nausea
Black Box Warning:
There is specific black box warning associated with neladenoson.
Contraindication/Caution:
The drug is contraindicated in following situations:
Hypersensitivity
Depressive Disorder
History of Suicidal behavior
Pregnancy Warnings:
Pregnancy category: N/A
Lactation:
Excretion of the drug in human breast milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Neladenoson binds with A2A receptors, and it stimulates the release of GABA.
It is a major inhibitory neurotransmitter which allows it to calm down brain activity.
Pharmacodynamics:
It inhibits glutamate release then it further reduces the brain activity and pushes towards sleep.
Pharmacokinetics:
Absorption:
It is absorbed rapidly within 1 to 2 hours after oral administration.
Distribution:
It enters the blood brain barrier to reach target sites in the brain.
Metabolism:
The metabolism process occurs under hepatic pathway.
Excretion:
The drug is excreted by using fecal route.
Administration:
The drug is available for oral intake.
Patient information leaflet:
Generic Name: neladenoson
Why do we use neladenoson?
It is studied for its efficacy and safety in patients with chronic heart failure.
Neladenoson is under investigation as a potential treatment for primary insomnia.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
