Beyond the Five: Humans May Have as Many as 33 Senses
December 25, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Coramine
Synonyms :
nikethamide
Class :
Respiratory Stimulant, Nicotinic acid derivative
Brand Name :
Coramine
Synonyms :
nikethamide
Class :
Respiratory Stimulant, Nicotinic acid derivative
Dosage Forms & Strengths
Injectable Solution
250 mg/ml
It is indicated in the treatment for respiratory depression
The recommended dose is 1-2 ml per one time a day via IV or SC
Dose Adjustments
Limited data is available
Injectable Solution
250 mg/ml
Refer to the adult dosing
Actions and Spectrum:
Actions:
nikethamide was used in the past for respiratory depression and neonatal apnea, which is now not recommended as the dose which is used in the therapy is close to toxic levels that lead to convulsions.
Spectrum:
The spectrum of nikethamide was used in the past for respiratory depression, and it has stimulant properties, which are used in drowsiness and fatigue. Now, it is not recommended due to its toxic effects with the usual dose.
Frequency not defined
Eye irritation
Nausea
Convulsions
Dizziness
Arrhythmia
Vasoconstriction
Restlessness
Shortness of breath
Irritation at the injection site
Black Box Warning:
It should be noted that nikethamide can cause dizziness, so driving and operating machinery should be avoided while on nikethamide.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Previously, nikethamide was used for respiratory depression as it is a respiratory and circulatory stimulant that shows its action around the cardiovascular and central nervous system by increasing the respiratory rate and vasodilation which leads to increased blood flow. Its stimulating properties will show increased alertness.
Pharmacodynamics:
nikethamide was used for respiratory depression as it is a respiratory and circulatory stimulant that shows its action around the cardiovascular and central nervous system by increasing the respiratory rate and vasodilation which leads to increased blood flow. Its stimulating properties will show increased alertness.
Pharmacokinetics:
Limited data is available.
Administration:
Nikethamide should be administered in a clinical setting via IV or SC. The patient’s condition determines the frequency of the drug.
Patient information leaflet
Generic Name: nikethamide
Pronounced: nye-KEH-thuh-myde
Why do we use nikethamide?
nikethamide was used in the past for respiratory depression, and it has stimulant properties, which are used in drowsiness and fatigue. Now, it is not recommended due to its toxic effects with the usual dose.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
