- March 15, 2022
- Newsletter
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Brand Name :
sular
Synonyms :
Nisoldipine, nisoldipina
Class :
Calcium channel blockers
Dosage Forms & Strengths
Extended-release tablet
8.5mg
17mg
20mg
25.5mg
30mg
34mg
40mg
Extended-release tablet
8.5mg
17mg
34mg
Extended-release hydrogel tablets (New formulation):
Initial dose:17mg orally every day
Maintenance dose:8.5 to 34mg orally once a day
Maximum dose:34mg/day
Extended-release coat-core tablets (Old formulation):
Initial dose:20mg orally every day
Maintenance dose:10 to 60mg orally once a day
Maximum dose:60mg/day
Extended-release hydrogel tablets (New formulation):
Initial dose: 8.5mg orally every day Maintenance dose: 8.5 to 34mg orally once a day Maximum dose: 34mg/day Extended-release coat-core tablets (Old formulation): Initial dose: 20mg orally every day Maintenance dose: 10 to 60mg orally once a day Maximum dose: 60mg/day
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hyperkalemic effect of calcium channel blockers
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may increase the serum concentration of CYP3A4 substrates
may increase the serum concentration
may increase the serum concentration
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
nisoldipine: they may enhance the serum concentration of CYP3A4 Inhibitors
nisoldipine: they may enhance the serum concentration of CYP3A4 Inhibitors
nisoldipine: they may enhance the serum concentration of CYP3A4 Inhibitors
nisoldipine: they may enhance the serum concentration of CYP3A4 Inhibitors
nisoldipine: they may enhance the serum concentration of CYP3A4 Inhibitors
the effect of nisoldipine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of nisoldipine
it increases the concentration of nisoldipine in serum
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 Inhibitors
may diminish the serum concentration of CYP3A4 Inducers
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may enhance the serum concentration of CYP2C9 inhibitors
may increase the hypotensive effect of anti-hypertensives
may decrease the antihypertensive effects
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect of anti-hypertensives
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the hypotensive effect
may increase the serum concentration
It may diminish the effect when combined with griseofulvin by CYP3A4 metabolism
it may diminish the therapeutic efficacy when combined with castor oil
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
Frequency defined:
>10%
Peripheral edema
Headache
1-10%
Palpitations
Angina severity
Pharyngitis
Dizziness
Vasodilation
Nausea
Sinusitis
<1%
Colitis
Alopecia
Anxiety
Diabetes mellitus
Dysphagia
Gingival hyperplasia
Anemia
Anorexia
Ischemia
Dyspepsia
Post-marketing reports
Vaginitis
Dysuria
Impotence
Urinary frequency
Pregnancy consideration: C
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: nisoldipine
Pronounced: [ nye-ZOL-di-peen]
Why do we use nisoldipine?
It is used to treat hypertension (high blood pressure) in adults
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