The Navigation Model of Therapy: Why Awareness Changes Everything
November 16, 2025
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Brand Name :
Oriahnn
Synonyms :
norethindrone acetate/estradiol/elagolix
Class :
Gonadotropin Releasing Hormone Antagonists
Brand Name :
Oriahnn
Synonyms :
norethindrone acetate/estradiol/elagolix
Class :
Gonadotropin Releasing Hormone Antagonists
Dosage Forms & Strengths
Copackaged capsules
300mg/1mg/0.5mg- elagolix/estradiol/norethindrone acetate fixed-dose capsule
elagolix capsule
300mg
2% ointment applied every 8 hours in the affected area
not indicated
Adverse drug reactions
Frequency Defined
>10%
Hot flush (22%)
Decreased bone mineral density (BMD) >3% (27%)
Increased diastolic blood pressure (11.3%)
1-10%
Alopecia (3.5%)
Depression (3%)
Increased systolic (7.1%)
Headache (9%)
Fatigue (6%)
Metrorrhagia (5%)
Pregnancy warnings:
US FDA pregnancy category: Not Assigned
Lactation:
Excreted into human milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: norethindrone acetate/estradiol/elagolix
Why do we use norethindrone acetate/estradiol/elagolix?
norethindrone acetate/estradiol/elagolix is a Gonadotropin Releasing Hormone Antagonists used to treat Uterine Leiomyomas.
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