- March 15, 2022
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Brand Name :
Atoxan, Celtect, Oxtin
Synonyms :
oxatomide
Class :
Antihistamines & Antiallergics
Dosage forms and strengths
Oral tablet
30 mg
Indicated for Allergic conditions
anhydrous substance- The recommended dose is 30 mg orally twice a day
Dosage forms and strengths
Oral tablet
30 mg
Indicated for Allergic conditions
anhydrous substance- at starting 0.5 mg/kg orally twice a day
The recommended Optimal dose is 0.5 to 1 mg/kg orally twice a day
Indicated for Allergic conditions
anhydrous substance- at starting 0.5 mg/kg orally twice a day
The recommended Optimal dose is 0.5 to 1 mg/kg orally twice a day
Refer adult dosing
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
oxatomide: they may increase the anticholinesterase effect of anticholinesterases
may increase the anti-cholinergic effect
may increase the anti-cholinergic effect of anti-cholinergic agents
may increase the anticholinergic of anticholinergic agents
may increase the anticholinergic effect of anticholinergic agents
may increase the anticholinergic effect of Anticholinergic Agents
may enhance the anti-cholinergic effect
may enhance the anti-cholinergic effect
may enhance the anti-cholinergic effect
may enhance the anti-cholinergic effect
may enhance the anti-cholinergic effect
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
it increases the effect of anticholinergic agents
Actions and Spectrum:
Action:
oxatomide is classified as a second-generation antihistamine. It binds to histamine H1 receptors in the body, specifically in the nose, eyes, and respiratory tract. By binding to these receptors, oxatomide prevents histamine from exerting its effects. This action helps reduce the allergic response, including itching, sneezing, and runny nose.
Spectrum:
Allergic rhinitis (hay fever): oxatomide can help relieve symptoms of allergy or watery eyes in individuals with seasonal or perennial allergies.
Allergic conjunctivitis: It can also effectively alleviate allergic conjunctivitis symptoms, which is inflammation of the eye’s conjunctiva due to allergies.
Frequency not defined
chest tightness
dry mouth
anorexia
constipation
diarrhoea
vomiting
Nausea
muscular weakness
dizziness
Sedation
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: Individuals with a known hypersensitivity or allergy to oxatomide or its components should not use this medication.
Severe liver impairment: oxatomide is primarily metabolized by the liver. People suffering from severe liver dysfunction might experience difficulties adequately processing the medication, which could result in potential toxic effects. Therefore, it is contraindicated in such cases.
Pregnancy and breast-feeding: The safety of oxatomide during pregnancy and breastfeeding has not been well-established. It is generally recommended to avoid using this medication during these periods unless the potential benefits outweigh the risks and are under a healthcare professional’s guidance.
Children under two years of age: oxatomide is typically not recommended for use in children under two years due to limited safety and efficacy data in this age group.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
oxatomide is an antihistamine drug used to relieve symptoms of allergies and watery eyes.
Pharmacodynamics:
oxatomide works as a competitive antagonist at H1 histamine receptors. By binding to H1 receptors and blocking the action of histamine, oxatomide helps alleviate these allergic symptoms.
Pharmacokinetics:
Absorption
oxatomide is well-absorbed when taken orally.
Distribution
It is distributed throughout the body, including the central nervous system (CNS).
Metabolism
oxatomide is extensively metabolized in the liver, primarily through the CYP2D6 enzyme system.
Excretion and Elimination
The primary route of excretion for these metabolites is through the urine.
Administration:
The route of administration is oral.
Patient information leaflet
Generic Name: oxatomide
Why do we use oxatomide?
Allergic Conditions: oxatomide is often prescribed to relieve symptoms associated with allergies. It can help alleviate symptoms like sneezing, runny nose, itching, and skin rashes.
Asthma: In some cases, oxatomide may be used as an adjunct therapy for asthma. It can help manage symptoms like coughing and wheezing, particularly when allergies trigger or exacerbate them.
Atopic Dermatitis: oxatomide may also be used to manage the itching and inflammation associated with atopic dermatitis (eczema). It can provide relief for some individuals with this skin condition.
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