Evaluating Match Rates Between OASIS Assessments and Medicare Claims Data
April 4, 2026
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Brand Name :
Sympatol
Synonyms :
p-synephrine
Class :
Nasal Decongestants Ophthalmologicals
Brand Name :
Sympatol
Synonyms :
p-synephrine
Class :
Nasal Decongestants Ophthalmologicals
Not indicated
Refer adult dosing
Actions and Spectrum:
Action:
Adrenergic Stimulation: oxedrine primarily acts as a sympathomimetic agent, meaning it stimulates the sympathetic nervous system. It does so by binding to and activating adrenergic receptors, particularly the alpha-1 and beta-3 adrenergic receptors.
Vasoconstriction: Activation of alpha-1 adrenergic receptors by oxedrine can lead to vasoconstriction, which is the narrowing of blood vessels. This can increase blood pressure and improve blood flow to certain areas of the body.
Frequency not defined
acute glaucoma
Bradycardia
Black Box Warning:
None
Contraindication/Caution:
Hypersensitivity: Individuals with a known hypersensitivity or allergic reaction to oxedrine or any of its components should avoid its use. Signs of hypersensitivity may include skin rash, itching, swelling, or severe dizziness.
Cardiovascular Disorders: oxedrine is contraindicated in patients with a history of cardiovascular disorders, such as hypertension, angina, arrhythmias, or congestive heart failure. The compound’s sympathomimetic properties may exacerbate these conditions and lead to potentially life-threatening complications.
Hyperthyroidism: Patients with hyperthyroidism, a condition characterized by an overactive thyroid gland, should avoid oxedrine. The drug’s stimulant effects can further stimulate thyroid function, potentially causing thyroid storm or exacerbating hyperthyroid symptoms.
Pregnancy and Lactation: oxedrine should be avoided during pregnancy unless the potential advantages clearly outweigh the potential risks, given the limited data available regarding its safety in pregnant individuals. Additionally, the drug may pass into breast milk, and its use is generally discouraged during lactation.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
oxedrine is a naturally occurring alkaloid compound found in some plants, primarily in the Citrus genus.
Pharmacodynamics:
Adrenergic Activity: oxedrine primarily acts as a sympathomimetic agent, which means it mimics the effects of the sympathetic nervous system’s neurotransmitters, such as norepinephrine and epinephrine. It exerts its effects by binding to adrenergic receptors in the body.
Alpha-Adrenergic Receptors: oxedrine has greater affinity for alpha-adrenergic receptors, particularly alpha-1 receptors. Activating these receptors leads to vasoconstriction (narrowing of blood vessels), potentially raising blood pressure.
Pharmacokinetics:
Absorption
oxedrine is readily absorbed from the gastrointestinal tract when taken orally.
Distribution
It is distributed throughout the body, including the brain, heart, and adipose tissue.
Metabolism
oxedrine is metabolized in the liver primarily by enzymes like catechol-O-methyltransferase (COMT).
Excretion and Elimination
Metabolites are excreted mainly in the urine.
Administration:
oxedrine supplements are available in various forms, including capsules, tablets, powders, and liquid extracts. Follow the specific product’s instructions for the correct dosage form.
Patient information leaflet
Generic Name: oxedrine
Why do we use oxedrine?
Blood Pressure Regulation:
oxedrine vasoconstrictive properties may be useful in managing low blood pressure, but it should be used with caution and under medical supervision.
Nasal Decongestant:
oxedrine has vasoconstrictive properties, means it can constrict blood vessels. In this regard, it has been used in nasal decongestant sprays and drops to relieve nasal congestion.
Weight Management:
oxedrine is often included in dietary supplements and weight loss products due to its purported ability to increase metabolic rate and energy expenditure.
It may help suppress appetite, making it easier for individuals to adhere to calorie-restricted diets.
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