- March 15, 2022
- Newsletter
- 617-430-5616
Menu
Brand Name :
Synonyms :
Class :
Patients who have not previously taken opioids (immediate release): 10 to 20 mg taken orally every 4 to 6 hours as required at first, and then adjusted as necessary.
Extended-release tablet initial dosing Patients who have not previously taken opioids or do not have a tolerance: should begin with a dose of 5 mg administered orally every 12 hours. The dosage should then be adjusted gradually in increments of 5 to 10 mg after every 3 to 7 days until a level is reached that effectively relieves pain while minimizing any potential adverse effects Patients who have developed tolerance to opioids: Patients who have been taking a minimum dosage of 60 mg/day orally for morphine, 25 mcg/hr transdermal fentanyl, 30 mg/day orally for oxycodone, 8 mg/day orally for hydromorphone, 25 mg/day orally for oxymorphone, or an equivalent amount of another opioid for a period of one week or more.
may have an increased Effect of CNS depressant when combined with serotonergic opioids
it increases the effect of CNS depressants
CNS depressants increase the effect of paraldehyde
CNS depressants increase the CNS depressing effect of thalidomide
CNS depressants increase the effect of flunarizine
it increases the effect of CNS depressants
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
may reduce the analgesic effect of Opioid agonists
It may enhance sedation when combined with a shepherd's purse
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
lofexidine may enhance the CNS depressant effect of CNS depressants
may increase the CNS depressant effect
may enhance the activity
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the CNS depressant effect
may increase the sedative effect of CNS depressants
may increase the CNS depressant effect
it increases the effect of CNS depressants