ozagrel hydrochloride

Action and Spectrum

Actions and Spectrum: 

Action: 

ozagrel hydrochloride has been demonstrated to lessen bronchial hyperresponsiveness to acetylcholine and leukotriene D4. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Abdominal discomfort 

Gastric discomfort 

Dizziness 

Sleepiness 

Allergic reactions 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Allergy: ozagrel hydrochloride is contraindicated if the patient is allergic to the drug or any component of the drug. 

Pregnancy and breast-feeding:  It should not be given to pregnant or breastfeeding women. There is a lack of comprehensive data on the use of ozagrel hydrochloride during pregnancy and lactation. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: ozagrel hydrochloride belongs to a class of thromboxane A2 synthase inhibitors. 

Pharmacodynamics:  

It works by suppressing the production of thromboxane A2, a substance that contributes to vasoconstriction and platelet aggregation. This action contributes to its antiplatelet and vasodilatory effects.  

Pharmacokinetics: 

Absorption 

ozagrel hydrochloride is absorbed in the gastrointestinal tract after oral administration. 

Distribution 

It distributes throughout the body, with a significant portion binding to plasma proteins. 

Metabolism 

The metabolism of ozagrel hydrochloride involves various enzymatic processes in the liver. 

Excretion and Elimination 

ozagrel and its metabolites are mainly excreted through urinary mode. 

Adminstartion

Administration:  

Ask the healthcare provider before using the drug for dosage frequency and condition treated. 

The preferred route of administration is oral. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: ozagrel hydrochloride 

Why do we use ozagrel hydrochloride?  

ozagrel hydrochloride is used to treat movement disorders linked to acute phase cerebral thrombosis and cerebrovascular spasms, which are signs of cerebral ischemia that occur following surgery for subarachnoid haemorrhage.