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Brand Name :
Oncaspar
Synonyms :
pegaspargase
Class :
Antineoplastic agents & asparaginase depleting agent
Brand Name :
Oncaspar
Synonyms :
pegaspargase
Class :
Antineoplastic agents & asparaginase depleting agent
Dosage Forms & Strengths
Solution, Injection:
750 units/ml
Note: Premedicate with acetaminophen, H1 antagonists, and H2 antagonists before 30 to 60 minutes of the administration of pegaspargase.
Administer with low molecular weight heparin in patients with a high risk of thromboembolism.
Dosage Forms & Strengths
Solution, Injection:
750 units/ml
Note: Premedicate with acetaminophen, H1 antagonists, and H2 antagonists before 30 to 60 minutes of the administration of pegaspargase.
Administer with low molecular weight heparin in patients with a high risk of thromboembolism.
Refer to adult dosing
drospirenone/ethinyl estradiol/levomefolate
may increase the thrombogenic effect of Hormonal Contraceptives.
They may increase the thrombogenic effect when combined with asparaginase Products
They may increase the thrombogenic effect when combined with asparaginase Products
They may increase the thrombogenic effect when combined with asparaginase Products
They may increase the thrombogenic effect when combined with asparaginase Products
etonogestrel/ethinyl estradiol
may increase the thrombogenic effect of Hormonal Contraceptives
It may diminish the therapeutic efficacy when combined with pegloticase
when both the drugs are combined, the risk or severity of adverse effects increases
Frequency defined:
>10%:
Hypersensitivity reaction
Antibody development
1% to 10%:
Cerebral thrombosis
Hyperglycemia
Hypoalbuminemia
Pancreatitis
Hyperbilirubinemia
Increased serum alanine aminotransferase
Increased serum aspartate aminotransferase
Postmarketing:
Thrombosis
Hyperammonemia
Increased serum cholesterol
Hemorrhage
Hepatic insufficiency
Pregnancy consideration: it may reflect side effects on the fetus if administered to pregnant women.
Lactation: excretion of pegaspargase in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Pegaspargase
Pronounced: pe-gas-par-gas
Why do we use pegaspargase?
Pegaspargase is used to treat acute lymphoblastic leukemia.
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