phencyclidine

Action and Spectrum

Actions and spectrum: 

Neurotransmitters are the form of signals that the N-methyl-D-aspartate (NMDA) receptor, an ionotropic receptor, receives from the dendrites of neurons. It is one of the brain’s primary excitatory receptors.

Positive ions must flow through the receptor’s channel portion for the normal physiological function of the activated receptor. As a result, PCP prevents neurons from depolarizing and interfering with brain and other nervous system processes. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Blurred vision 

Confusion 

Dizziness 

Myosis 

Nystagmus 

Speech problems 

Stupor 

Disorientation 

Anxiety 

Tachycardia

Black Box Warning

Black Box Warning  

Schedule II drug. To be sold only on the advice of the doctor 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity  

Analgesia 

Cardiovascular effects 

Renal failure 

Pregnancy / Lactation

Pregnancy consideration:  

USFDA pregnancy category: Class A and schedule-II drug 

Lactation:  

Safety and efficacy study not established 

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester. 

Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

Phencyclidine is a dissociative anesthetic 

Pharmacodynamics: 

Phencyclidine is an antagonist of the NMDA receptor  

Pharmacokinetics: 

Absorption 

PCP absorption was rapid with maximum measured plasma concentration 

Distribution 

Volume of distribution of phencyclidine is found to be 6.2l/kg 

Metabolism 

It undergoes hepatic metabolism 

Elimination and excretion 

Phencyclidine is known to get eliminated through urine acidification  

Half-life: 

Adminstartion

Administration: 

To be taken as directed by the physician 

Patient Information Leaflet

Patient information leaflet 

Generic Name: phencyclidine  

Why do we use phencyclidine? 

Phencyclidine is a dissociative anesthetic used for human and veterinary use. It works as an antagonist of NMDA receptors.