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Brand Name :
Preludin
Synonyms :
phenmetrazine
Class :
Anti-Obesity agents
Brand Name :
Preludin
Synonyms :
phenmetrazine
Class :
Anti-Obesity agents
Dosage Forms & Strengths
Dosage Forms & Strengths
Safety and efficacy not established.
Refer adult dosing
Actions and Spectrum:
Phenmetrazine is used in weight loss and reducing appetite. It works by increasing the neurotransmitters like norepinephrine and dopamine, resulting in increased heart rate, increased alertness, improved mood, energy, and a euphoria sensation.
Frequency not defined
Dizziness
Palpitations
Nausea
Dry Mouth
Hyperventilation
Headache
Black box warning:
None
Contraindications/caution:
Contraindications:
Hyperthyroidism
Hypersensitivity
Cardiovascular Issues
Psychiatric Disorders
Caution:
Renal impairment
Liver impairment
Pregnancy/Lactation
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Phenmetrazine works by increasing the release and decreasing the reuptake of neurotransmitters and prolonging their effects.
Pharmacokinetics:
Absorption
Phenmetrazine gets absorbed from gastrointestinal tract.
Distribution
It is distributed to various parts of the body, including brain.
Metabolism
The metabolism takes place through liver by CYP2D6 enzymes.
Elimination and Excretion
Phenmetrazine has short half-life, it gets eliminated from the body through urine.
Administration:
Phenmetrazine is taken orally as tablets.
Patient information leaflet
Generic Name: phenmetrazine
Why do we use phenmetrazine?
Phenmetrazine is used in the treatment of obesity, as it helps to suppress appetite and increase alertness in the body.
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