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Brand Name :
N/A
Synonyms :
phenserine
Class :
Non-competitive acetylcholinesterase inhibitor
Brand Name :
N/A
Synonyms :
phenserine
Class :
Non-competitive acetylcholinesterase inhibitor
Adult dosing
Alzheimer’s Disease (off-label)
In-vivo studies suggest that administer dose of 5 mg orally every 12 hours for the starting 4 weeks of the investigation and then dose of 10 mg orally every 12 hours for the remaining 4 weeks
It is indicated for mild to moderate Alzheimer’s disease
In-vivo studies suggests that administer dose of 5 mg orally every 12 hours for the starting 4 weeks of the investigation and then dose of 10 mg orally every 12 hours for the remaining 4 weeks
Safety and efficacy studies are not established
Refer to adult dosing
Actions and spectrum:
Phenserine is a selective, and reversible acetylcholinesterase inhibitor. It is well known to possess a positive effect on the memory and cognition of Alzheimer’s patients. The possibility of increased concentration in the brain is reduced problem of drug toxicity and side effects in a very fast way.
Adverse reactions
Nausea
Vomiting
Black box warning
No specific warning is available
Contraindications/Caution
Contraindications
Hypersensitivity
Cautions
Cardiac conditions
Seizures or epilepsy
Pregnancy & breastfeeding:
Pregnancy consideration:
USFDA pregnancy category: Not assigned
Breastfeeding warnings:
Data about the excretion of the drug into human milk is not known
Pregnancy category:
Pharmacology:
Phenserine is phenyl carbamate derivative of physostigmine and is a next generation inhibitor of AChE (acetylcholinesterase).
Pharmacodynamics:
Phenserine in invitro decreases the secretion of beta-APP in the cerebrospinal fluid (CSF). A study on human cultured brain cells has shown that it is feasible for this drug to affect the synthesis of β-APP that might cure and inhibit the accumulation of β-amyloid.
Pharmacokinetics:
Absorption
Well absorbed
Distribution
It has a high affinity for plasma proteins.
Metabolism
Metabolized by Cytochrome P450 enzymes.
Excretion
Metabolites excreted by kidneys.
Administration:
It is taken orally and available in tablet form.
Patient information leaflet
Generic Name: phenserine
Why do we use phenserine?
Phenserine is a potent inhibitor of acetylcholinesterase that increases acetylcholine levels in the brain potentially improving cognitive function in Alzheimer’s patients. It also shows neuroprotective properties protecting neurons from oxidative stress and amyloid-beta toxicity.
Phenserine reduces the expression of amyloid precursor protein contributing to neuronal damage and cognitive decline.
It may enhance cognitive function in Alzheimer’s patients and other dementia forms.
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