phenserine

Action and Spectrum

Actions and spectrum: 

Phenserine is a selective, and reversible acetylcholinesterase inhibitor. It is well known to possess a positive effect on the memory and cognition of Alzheimer’s patients. The possibility of increased concentration in the brain is reduced problem of drug toxicity and side effects in a very fast way. 

Drug Interaction

Adverse Reaction

Adverse reactions 

Nausea 

Vomiting  

Black Box Warning

Black box warning 

No specific warning is available  

Contraindication / Caution

Contraindications/Caution 

Contraindications 

Hypersensitivity 

Cautions 

Cardiac conditions 

Seizures or epilepsy 

Pregnancy / Lactation

Pregnancy & breastfeeding: 

Pregnancy consideration: 

USFDA pregnancy category: Not assigned 

Breastfeeding warnings: 

Data about the excretion of the drug into human milk is not known 

Pregnancy category: 

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 
• Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women. 
• Category N: No data for the drug under this category is available. 

Pharmacology

Pharmacology: 

Phenserine is phenyl carbamate derivative of physostigmine and is a next generation inhibitor of AChE (acetylcholinesterase).  

Pharmacodynamics: 

Phenserine in invitro decreases the secretion of beta-APP in the cerebrospinal fluid (CSF). A study on human cultured brain cells has shown that it is feasible for this drug to affect the synthesis of β-APP that might cure and inhibit the accumulation of β-amyloid. 

Pharmacokinetics: 

Absorption 

Well absorbed 

Distribution 

It has a high affinity for plasma proteins. 

Metabolism 

Metabolized by Cytochrome P450 enzymes. 

Excretion 

Metabolites excreted by kidneys. 

Adminstartion

Administration: 

It is taken orally and available in tablet form. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: phenserine 

Why do we use phenserine? 

Phenserine is a potent inhibitor of acetylcholinesterase that increases acetylcholine levels in the brain potentially improving cognitive function in Alzheimer’s patients. It also shows neuroprotective properties protecting neurons from oxidative stress and amyloid-beta toxicity.  

Phenserine reduces the expression of amyloid precursor protein contributing to neuronal damage and cognitive decline.  

It may enhance cognitive function in Alzheimer’s patients and other dementia forms.