picloxydine

Action and Spectrum

Actions and Spectrum: 

picloxydine is an anti-infective agent used in the treatment of eye infections. It has bactericidal activity. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Corneal damage 

Irritation 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity 

Cautions: 

• Renal impairment  
• Liver impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

The drug should be avoided during pregnancy. 

Breastfeeding warnings:  

It is unknown whether picloxydine is secreted in the breast milk.  

Pregnancy category: 

Category A: Well-controlled and satisfactory studies show no risk to the fetus in the initial or later trimester. 

Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

picloxydine is an anti-infective agent used in the treatment of eye infections. It has bactericidal activity. 

Pharmacodynamics: 

picloxydine is an anti-infective agent used in the treatment of eye infections. It has bactericidal activity. 

Pharmacokinetics: 

Absorption: 

picloxydine is absorbed through the lachrymal route. 

Distribution:  

It. 

Metabolism: 

The metabolism is unknown. 

Elimination and Excretion: 

The drug is excreted through the renal route. 

Adminstartion

Administration: 

picloxydine is administered through the ophthalmic route as eye drops. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: picloxydine  

Pronounced as: pik-lox-i-deen 

Why do we use picloxydine? 

picloxydine is an antiseptic of bisbiguanide class.  

It works bacteriostatically on the various gram-positive and gram-negative bacteria in conjunctiva. 

It is used as an antiseptic for various eye infections.