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Brand Name :
Vercyte, Vercite
Synonyms :
Pipobroman, pipobromanum
Class :
Miscellaneous alkylating agents/antineoplastic agents
Brand Name :
Vercyte, Vercite
Synonyms :
Pipobroman, pipobromanum
Class :
Miscellaneous alkylating agents/antineoplastic agents
Dosage Forms & Strengths
Tablets
50mg
100mg
Dosage Forms & Strengths
Safety and efficacy studies are not established
Refer to adult dosing
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of thrombosis may be increased
the risk of methemoglobinemia may be increased
the risk of immunosuppression may be increased
the risk of methemoglobinemia may be increased
the risk of adverse effects may be increased
the risk of methemoglobinemia may be increased
the risk of thrombosis may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
Actions and spectrum:
Pipobroman is one of the antineoplastic agents. It is a piperazine derivative, and many DNA alkylating agents share a similar chemical structure with it. Pipobroman has proven to be clinically effective in treating polycythemia vera and essential thrombocythemia.
Frequency not defined
Amenorrhea
Pigmentation on skin
Pulmonary fibrosis
Bone marrow aplasia
Diarrhea
Abdominal cramping
Anorexia
Bone marrow depression
Hypotension
Dizziness
Drowsiness
Headache
No special warnings are available for this drug
Pregnancy consideration:
USFDA pregnancy category: X
Lactation:
Data about the excretion of pipobroman into human milk is not known
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pipobroman is an antineoplastic drug
Pharmacodynamics:
Antineoplastic agents include pipobroman. It is specifically a derivative of piperazine, whose chemical structure is like many DNA alkylating agents. Pipobroman has demonstrated clinical efficacy in treating essential thrombocythemia and polycythemia vera.
Pharmacokinetics:
Absorption
Pipobroman is absorbed rapidly from the gastrointestinal tract
Limited data about distribution, metabolism, and excretion is not available
To be administered orally before or after food
Patient information leaflet
Generic Name: pipobroman
Why do we use pipobroman?
Pipobroman is an alkylating agent and a piperazine bromide derivative. In order to fulfill its function, pipobroman either inhibits DNA and RNA polymerase or decreases the incorporation of pyrimidine nucleotides into DNA. Pipobroman is helpful in the study of cancer, particularly myeloproliferative neoplasms and polycythemia vera.
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