piracetam/ginkgo biloba/vinpocetine

Action and Spectrum

Actions and Spectrum 

piracetam mechanism of action involves modulating neurotransmission and improving cerebral blood flow. piracetam is used to improve memory, learning, and overall cognitive function. It may also have a mild stimulatory effect and is sometimes used to support mental clarity and focus.  

ginkgo biloba is an herbal supplement derived from the leaves of the ginkgo biloba tree. It contains bioactive compounds such as flavonoids and terpenoids that have antioxidant and vasodilatory properties, helping to improve blood flow and protect against oxidative damage. 

vinpocetine is a synthetic compound derived from the periwinkle plant and is sometimes used as a dietary supplement. Its mechanism of action involves enhancing cerebral blood flow, improving oxygen and nutrient supply to the brain, and offering neuroprotective effects. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Rash 

Nervousness 

Abnormality of voluntary movements 

Weight gain 

Flushing  

Upset stomach 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

• Known hypersensitivity or allergy to piracetam/ ginkgo biloba/vinpocetine should contraindicated. 
• piracetam should be used cautiously in individuals with bleeding disorders. 
• ginkgo biloba should be used with caution in individuals with diabetes. 
• vinpocetine is metabolized by the liver, so individuals with liver issues should use it cautiously. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology 

piracetam is known for its subtle cognitive effects, including potential improvements in memory, learning, and mental clarity.  

ginkgo biloba contains bioactive compounds such as flavonoids and terpenoids that have antioxidant properties and improve blood flow.  

vinpocetine, derived from the periwinkle plant, is believed to enhance cerebral blood flow and oxygen supply to the brain.  

Pharmacodynamics 

piracetam may influence the fluidity and integrity of neuronal cell membranes, which can affect signal transduction and receptor function. 

ginkgo biloba’s flavonoids and terpenoids have antioxidant properties, which can help protect cells from oxidative damage. 

vinpocetine is a vasodilator that can increase blood flow in cerebral blood vessels, which may improve oxygen and nutrient delivery to the brain. 

Pharmacokinetics 

Absorption   

piracetam/ginkgo biloba/vinpocetine is well-absorbed after oral intake. 

Distribution 

piracetam/ginkgo biloba/vinpocetine crosses the blood-brain barrier and is distributed throughout the body. 

Metabolism 

piracetam/ginkgo biloba/vinpocetine is metabolized in the liver. 

Elimination and excretion 

piracetam/ginkgo biloba/vinpocetine are excreted in the urine and feces.

Adminstartion

Administration 

piracetam/ginkgo biloba/vinpocetine is a combination drug available in the form of tablet for oral intake.

Patient Information Leaflet

Patient information leaflet 

Generic Name: piracetam/ginkgo biloba/vinpocetine 

Why do we use piracetam/ginkgo biloba/vinpocetine? 

Cognix Plus (piracetam/ginkgo biloba/vinpocetine) is a combination medicine is used as a cognitive and memory enhancer. 

It also helps to improve brain function, enhance focus, and increase the blood flow to the brain.