Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
N/A
Synonyms :
pirarubicin
Class :
Cytotoxic Chemotherapy, Antineoplastic Agents
Brand Name :
N/A
Synonyms :
pirarubicin
Class :
Cytotoxic Chemotherapy, Antineoplastic Agents
Dosage Forms & StrengthsÂ
Solution Â
25 mg Â
Administer dose of 25 to 50 mg/m2 intravenously as per body surface area (BSA) in every 3 to 4 weeks
Given as injection over 5 to 10 minutes into a rapidly flowing infusion of 5% glucose
Not determined Â
Refer to adult dosingÂ
Actions and SpectrumÂ
pirarubicin inhibits the enzyme topoisomerase II. This enzyme is involved in managing the supercoiling of DNA during replication and transcription.  pirarubicin induces DNA strand breaks and further disrupts DNA function.
Frequency not defined Â
AlopoeciaÂ
Red coloration of urineÂ
Hypersensitivity reactions Â
Facial flushingÂ
Conjunctivitis and lachrymationÂ
Vomiting Â
StomatitisÂ
Black Box WarningÂ
None Â
Contraindication/Caution:Â Â
N/AÂ
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
pirarubicin can intercalate between the base pairs of DNA. This disrupts the structure of DNA and inhibits its replication and transcription. Â
PharmacodynamicsÂ
pirarubicin can produce reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide. These free radicals can induce oxidative stress and cause damage to cellular components, including DNA, proteins, and lipids.Â
PharmacokineticsÂ
Absorption  Â
pirarubicin is rapidly absorbed directly into the bloodstream after intravenous (IV) administration.Â
DistributionÂ
pirarubicin is distributed throughout the body, including various tissues. Â
MetabolismÂ
pirarubicin undergoes metabolic conversion primarily in the liver. Â
Elimination and excretionÂ
pirarubicin is primarily excreted through the bile into the feces.
AdministrationÂ
pirarubicin is typically administered through intravenous (IV) route.Â
Patient information leafletÂ
Generic Name: pirarubicinÂ
Why do we use pirarubicin?Â
pirarubicin is used in the treatment of breast cancer, both as a single-agent therapy and in combination with other chemotherapy drugs. pirarubicin is indicated in the management of bladder cancer. pirarubicin is also used in the treatment of ovarian cancer.Â
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