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Brand Name :
N/A
Synonyms :
pirarubicin
Class :
Cytotoxic Chemotherapy, Antineoplastic Agents
Brand Name :
N/A
Synonyms :
pirarubicin
Class :
Cytotoxic Chemotherapy, Antineoplastic Agents
Dosage Forms & Strengths
Solution
25 mg
Administer dose of 25 to 50 mg/m2 intravenously as per body surface area (BSA) in every 3 to 4 weeks
Given as injection over 5 to 10 minutes into a rapidly flowing infusion of 5% glucose
Not determined
Refer to adult dosing
Actions and Spectrum
pirarubicin inhibits the enzyme topoisomerase II. This enzyme is involved in managing the supercoiling of DNA during replication and transcription. pirarubicin induces DNA strand breaks and further disrupts DNA function.
Frequency not defined
Alopoecia
Red coloration of urine
Hypersensitivity reactions
Facial flushing
Conjunctivitis and lachrymation
Vomiting
Stomatitis
Black Box Warning
None
Contraindication/Caution:
N/A
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
pirarubicin can intercalate between the base pairs of DNA. This disrupts the structure of DNA and inhibits its replication and transcription.
Pharmacodynamics
pirarubicin can produce reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide. These free radicals can induce oxidative stress and cause damage to cellular components, including DNA, proteins, and lipids.
Pharmacokinetics
Absorption
pirarubicin is rapidly absorbed directly into the bloodstream after intravenous (IV) administration.
Distribution
pirarubicin is distributed throughout the body, including various tissues.
Metabolism
pirarubicin undergoes metabolic conversion primarily in the liver.
Elimination and excretion
pirarubicin is primarily excreted through the bile into the feces.
Administration
pirarubicin is typically administered through intravenous (IV) route.
Patient information leaflet
Generic Name: pirarubicin
Why do we use pirarubicin?
pirarubicin is used in the treatment of breast cancer, both as a single-agent therapy and in combination with other chemotherapy drugs. pirarubicin is indicated in the management of bladder cancer. pirarubicin is also used in the treatment of ovarian cancer.
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