- May 27, 2022
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Brand Name :
Mithracin
Synonyms :
Plicamycin
Class :
Antineoplastic Agents and RNA synthesis inhibitor
Dosage forms & strengths:
Solution for injection
2.5 mg
It is used for malignant tumors of the testis where the treatment by surgery/radiation is unsuccessful :
25 - 30
mcg
or 0.025-0.030 mg/kg
Continue the treatment for 8-10 days until disease progression or unacceptable toxicity occurs
Therapy should not exceed more than ten daily doses
The individual daily dose should not exceed 0.030 mg/kg
0.025
mg/kg
once a day
3 - 4
days
0.025 mg/kg per day for 3 or 4 days
0.025
mg/kg
once a day
3 - 4
days
0.025 mg/kg per day for 3 or 4 days
measles, mumps, rubella, and varicella vaccine, live (Rx)
may diminish the therapeutic effect
measles mumps and rubella vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
smallpox (vaccinia) vaccine, live
may diminish the therapeutic effect
may diminish the therapeutic effect
respiratory syncytial virus vaccine, adjuvanted
may decrease the therapeutic effect when combined with vaccine
respiratory syncytial virus (RSV) vaccine
may decrease the therapeutic effect when combined with vaccine
poliovirus vaccine, live, trivalent
may decrease the therapeutic effect when combined with vaccine
poliovirus vaccine inactivated
may decrease the therapeutic effect when combined with vaccine
may have an increased nephrotoxic effect when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may decrease the therapeutic effect when combined with bacillus clausii
sodium picosulfate, citric acid, and magnesium oxide
may decrease the therapeutic effect when combined with sodium picosulfate
may decrease the therapeutic effect when combined with typhoid vaccine
antibiotics: they may decrease the therapeutic effect of sodium picosulfuric acid
When both drugs are combined, there may be an increased risk of bleeding and sometimes fatal hemorrhage
When both drugs are combined, there may be an increased risk of bleeding and fatal hemorrhage
When both drugs are combined, there may be an increased risk of bleeding and sometimes fatal hemorrhage
When both drugs are combined, there may be an increased risk of severe and potentially fatal infections
When both drugs are combined, there may be a decreased therapeutic effect of the vaccine
When both drugs are combined, there may be an increased risk of bleeding and sometimes fatal hemorrhage
When both drugs are combined, there may be an increased risk of bleeding and fatal hemorrhage
When both drugs are combined, there may be an increased risk of severe and potentially life-threatening infections
When both drugs are combined, there may be an increased risk of bleeding and sometimes fatal hemorrhage
When both drugs are combined, there may be an increased risk of severe and potentially life-threatening infections
When both drugs are combined, there may be an increased risk of bleeding and fatal hemorrhage
may decrease the therapeutic effect when combined with bcg
may decrease the therapeutic effect when combined with cholera vaccine
antibiotics decrease the efficacy of BCG intravesical
it decreases the efficacy of antibiotics
When both drugs are combined, there may be a decreased therapeutic effect of the vaccine
When both drugs are combined, there may be an increased risk of severe and potentially life-threatening infections
When both drugs are combined, there may be an increased risk of severe and possibly life-threatening infections
When both drugs are combined, there may be an increased risk of severe and potentially life-threatening infections
When both drugs are combined, there may be an increased risk of adverse effects
When both drugs are combined, there may be an increased risk of adverse effects
When both drugs are combined, there may be a decreased therapeutic effect of the vaccine
When both drugs are combined, there may be an increased risk of bleeding
When both drugs are combined, there may be an increased risk of bleeding
When both drugs are combined, there may be an increased risk of bleeding
When both drugs are combined, there may be an increased risk of bleeding
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with immune checkpoint inhibitors
may decrease the therapeutic effect when combined with lactobacillus and estriol
BCG Vaccine live: they may decrease the therapeutic effect of antibiotics
When both drugs are combined, there may be a decreased plasma concentrations of oral quinolone antibiotics
when both drugs are combined, there may be a decreased plasma concentrations of oral quinolone antibiotics
antibiotics decrease the efficacy of thiamine by altering the gut flora
Adverse drug reactions:
Frequency not defined
Bloody stools
Swelling of face
Nose bleeding
Skin rash
Sore throat
Bruising
Vomiting of blood
Yellow eyes or skin
Drowsiness
Fever
Headache
Mental depression
Pain at place of injection
Unusual tiredness
Weakness
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Patient Information Leaflet
Generic Name: Plicamycin (Rx)
Pronounced: Plye kay mye’ sin
Why do we use Plicamycin?
Plicamycin is an antineoplastic drug used to treat cancers like testicles. it is also used to treat cancers that are related to hypercalcemia and hypercalciuria.
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