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Brand Name :
N/A
Synonyms :
pociredir, FTX 6058
Class :
Antianemics, EED inhibitors, allosteric PRC2 inhibitor
Brand Name :
N/A
Synonyms :
pociredir, FTX 6058
Class :
Antianemics, EED inhibitors, allosteric PRC2 inhibitor
Dosage forms and strength
It is an investigational drug studied for its effectiveness in the treatment of sickle cell disease
Pediatric
Not determined
Actions and spectrum:
Pociredir works by stimulating the expression of fetal hemoglobin. It is an inhibitor of polycomb repressive complex 2 class.
None
Black Box warning
None
Contraindication/Caution:
None
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Pociredir is an antianemia agent. It belongs to the allosteric PRC2 inhibitor (EED) class.
Pharmacodynamics:
Pociredir is designed to induce fetal hemoglobin expression. This is used to compensate mutated adult hemoglobin in sickle cell disease.
Pharmacokinetics:
Limited information is available on ADME.
Administration:
The route of administration is not fully known.
Patient information leaflet
Generic Name: pociredir
Why do we use pociredir?
Pociredir is an inhibitor of EED (embryonic ectoderm development). It is under investigation for its treatment in sickle cell disease.
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