podophyllotoxin

Action and Spectrum

Actions and Spectrum: 

Actions: 

A few studies discovered that podophyllotoxin has significant use to treat genital warts with lowest penetration and localized activity. If drug spreads through out the skin it will show less effective when compared to tincture which is located on hair follicles. 

Spectrum: 

Podophyllotoxin are crucial with etoposide serves as a potential chemotherapeutic drug and continuous innovation and research are required to solve gaps in this study. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Vomiting 

Application site reactions 

Dizziness 

Smarting 

Black Box Warning

Black Box Warning: 

Podophyllotoxin shows allergic and systemic toxicity. 

Contraindication / Caution

Contraindication/Caution: 

Hypersensitivity, pediatrics under 12, and renal and hepatic impairment. 

Pregnancy / Lactation

Pregnancy Warnings: 

Pregnancy category: C 

Lactation: 

Excretion of the drug into human breast milk is unknown 

Pregnancy Categories: 

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester. 

Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women. 

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

Podophyllotoxin In the late S and early G2 phases of the cell cycle probably blocks topoisomerase II stabilizing the transient breaks it causes. Though the precise mode of action is not known with this interference stops DNA replication and unwinding by interfering with the DNA repair process. 

Pharmacodynamics: 

Podophyllotoxin is used to remove certain warts on genital skin because of its improved formulation increases both its safety and effectiveness in specific dermatological applications. 

Pharmacokinetics: 

Absorption 

systemic absorption reported in one to two hours ranging from 0.1 to 1.5 mL. 

Elimination and Excretion 

The half-life is 1 to 4.5 hours. 

Adminstartion

Administration: 

Before applying this drug it’s crucial to thoroughly cleanse and dry the affected area to ensure effective medication administration. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: podophyllotoxin 

Pronounced: POD-oh-fuh-luh-TOX-in 

Why do we use podophyllotoxin? 

Podophyllotoxin is applied topically to treat genital warts, skin diseases, and human papillomavirus. Its antimitotic properties warts shows smaller and less widespread and it prevents cells from dividing and proliferating by interfering with the activity of microtubules within the cells.