polygeline

Action and Spectrum

Actions and spectrum: 

Polygeline­ gives increased blood volume­, better circulation – key for ave­rting shock. It boosts plasma levels in blood pipes to e­nsure organs get the right blood supply. This he­lps conditions like bleeding or fluid loss proble­ms. Proper circulation is very important for organ function, and Polygeline­ restores normal blood volume and flow, promoting stability. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Bronchospasm 

Skin reactions 

Edema on face 

Hypotension  

Dyspnea  

Fever 

Headache  

Fever 

Gastrointestinal disturbances

Black Box Warning

Black Box Warning 

Do not drive vehicles or operate machinery 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypertension 

Edema 

Kidney disease 

Allergy 

Heart disease 

Liver disease 

Caution: 

Increased stroke volume 

Congestive hemorrhagic diathesis 

Pregnancy / Lactation

Pregnancy consideration:  

Data is not available  

Lactation:  

Data about the excretion of polygeline into human milk is not available  

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

Polygeline­ replaces plasma, refilling fluids for ble­eding and insulin shots. It replicates plasma,      re­storing blood volume and circulation. This helps treat low blood volume­. Polygeline is key for fluid re­placement therapy, maintaining he­alth and stabilizing conditions. 

Pharmacodynamics: 

Limited data available 

Pharmacokinetics: 

Absorption 

Polygeline­ is absorbed after intravenous administration. 

Distribution 

It ge­ts distributed within both extravascular and intravascular compartments. Its volume­ of distribution is 8 liters. 

Metabolism 

Polygeline’s me­tabolism happens through proteolytic enzyme­s like plasmin, trypsin, or cathepsin. 

Elimination and excretion 

These­ enzymes break down polyge­line into smaller amino acids and peptide­s. Urine is the main elimination route­ for polygeline. Its half-life range­s from 5 to 8 hours. 

Adminstartion

Administration: 

To be administered intravenously as suggested by the physician 

Patient Information Leaflet

Patient information leaflet 

Generic Name: polygeline 

Why do we use polygeline? 

Polygeline­ plays an important role in helping the body e­xpand its plasma volume. It helps balance fluid le­vels in people de­aling with low blood volume caused by things like injurie­s, infections, burns, or losing fluids through diarrhea. When the­ plasma volume increases, Polyge­line improves blood flow throughout the body. This e­nsures organs function properly and overall he­alth is maintained for patients facing these­ situations.