Potassium acid phosphate

Action and Spectrum

Action and Spectrum:

Phosphate ions buffer is intracellular fluid hence it is important for hydrogen ion excretion. Phosphate ions are essential for energy, bone mineralization, and cellular functions.

Drug Interaction

Adverse Reaction

Frequency not defined:

Diarrhea

Bradycardia

Hyperkalemia

Hypocalcemia

Tetany

Phosphate intoxication

Local tissue necrosis with extravasation

Weakness

Nausea/vomiting

Stomach pain

Flatulence

Dyspnea

Black Box Warning

Black box warning:

None

Contraindication / Caution

Contraindications/caution:

Contraindication:

Hyperphosphatemia

Infected phosphate stones

Caution:

Severe renal impairment

Hyperkalemia

Cardiac disease

Pregnancy / Lactation

Pregnancy Warnings:

Pregnancy category: N/A

Lactation: Excretion of the drug into the human breast milk is unknown

Pregnancy categories:

• Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
• Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
• Category N: There is no data available for the drug under this category.

Pharmacology

Pharmacology:

The compound lowers urinary pH to release hydrogen ions that combine with bicarbonate.

Oral phosphates increase serum phosphate and decrease urinary calcium levels.

Pharmacodynamics:

Phosphate is a key intracellular anion essential for energy metabolism and vital metabolic reactions in all tissues.

Phosphate influences calcium levels and plays a key role in hydrogen ion excretion.

Pharmacokinetic:

Absorption:

It is well absorbed from upper gastrointestinal tract after oral intake.

Distribution:

It enters cells from extracellular fluid through active transport.

Excretion and elimination:

It is excreted through renal route.

Adminstartion

Administration:

It is available in tablet form for oral use.

Patient Information Leaflet

Patient information leaflet:

Generic Name: potassium acid phosphate

Why do we use potassium acid phosphate?

Potassium acid phosphate is used to treat hypophosphatemia.

It is indicated to prevent kidney stones and urinary tract infections.