Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
First Progesterone MC10, Menopause Formula Progesterone, Prometrium
Synonyms :
progesterone
Class :
Progestins
Brand Name :
First Progesterone MC10, Menopause Formula Progesterone, Prometrium
Synonyms :
progesterone
Class :
Progestins
Dosage Forms & Strengths
Solution
50 mg/ml
Cream
16.9 mg/1ml
Gel
4 %
Take a dose of 400 mg orally one time in at bedtime up to 10 days
Administer Dose of 45 mg vaginally in form of gel every alternate day
Administer dose of 5 to 10 mg intramuscularly once daily for 6 doses
Administer initial dose of 100 mg vaginally 2 to 3 times daily
Not determined
Refer to adult dosing
may decrease the therapeutic effect when combined with progesterone
triamcinolone acetonide/nystatin
may decrease the therapeutic effect when combined with progesterone
may decrease the therapeutic effect when combined with progesterone
methenamine/sodium salicylate/benzoic acid
may decrease the therapeutic effect when combined with progesterone
may decrease the therapeutic effect when combined with progesterone
the effect of progesterone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
may decrease the therapeutic effect of antifungal agents
it may diminish the metabolism when combined with diosmin
may decrease the therapeutic effect of Antifungal Agents
Actions and Spectrum
Progesterone works in conjunction with estrogen to regulate the menstrual cycle. During the menstrual cycle, it helps prepare the uterine lining for a potential pregnancy. In early pregnancy, the corpus luteum produces progesterone.
Frequency not defined
Bloating
Joint pain
Headache
Constipation
Heartburn
Drowsiness
Dizziness
Breast pain
Mood changes
Vaginal discharge
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Progesterone prepares the uterine lining for implantation of a fertilized egg. It promotes the development of a secretory endometrium, which is necessary for embryo implantation.
Pharmacodynamics
Progesterone primarily binds to and activates progesterone receptors, which exist in two forms: PR-A and PR-B.
These receptors are present in various tissues, including the uterus, mammary glands, brain, and other reproductive organs.
Pharmacokinetics
Absorption
When administered orally, progesterone undergoes extensive first-pass metabolism in the liver.
Distribution
Progesterone is distributed to various tissues.
Metabolism
Progesterone undergoes hepatic metabolism.
Elimination and excretion
Progesterone is excreted through the kidneys.
Administration
Progesterone is available in capsule, gel, and capsule forms.
It is administered as oral, vaginal, and intramuscular routes.
Patient information leaflet
Generic Name: progesterone
Why do we use progesterone?
Progesterone used as contraceptives for birth control in the form of progestin-only pills, injections, implants, and intrauterine devices.
Progesterone is used in women with a history of preterm birth to reduce the risk of recurrent preterm labor.
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