propantheline

Action and Spectrum

Action and spectrum: 

Propantheline blocks the action of acetylcholine at muscarinic receptors by reducing sweat production. It manages gastrointestinal disorders and can be used as off-label for irritable bowel syndrome, urinary incontinence, and bladder disorders. 

Drug Interaction

Adverse Reaction

Adverse drug reactions:   

Frequency Defined  

>10%  

Dry skin  

Decreased sweating  

Constipation  

Dry mouth  

Frequency Not Defined  

Tachycardia  

Dysphagia  

Blurred vision  

Sedation  

Urinary retention  

Black Box Warning

Blackbox warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Hypersensitivity 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy Category: C 

Breastfeeding warnings:  

The release of the drug into the human breastmilk is unknown 

Pregnancy Categories:      

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.      
• Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women      
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women      
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits      
• Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.      
• Category N: There is no data available for the drug under this category  

Pharmacology

Pharmacology: 

Pharmacodynamics: 

Propantheline inhibits acetylcholine action at muscarinic receptors in sweat glands, gastrointestinal tract, and urinary bladder that affects sweat secretion, reducing motility, and relaxing smooth muscle. 

Pharmacokinetics: 

Absorption 

Well absorbed 

Distribution 

It crosses blood-brain barrier to some extent and is distributed widely throughout the body. 

Metabolism 

Metabolized by oxidation and conjugation processes. 

Excretion 

Excreted in urine with a small portion eliminated in feces. 

Adminstartion

Patient Information Leaflet

Patient Information Leaflet 

Generic Name: propantheline  

Pronunciation: proe-PAN-the-leen 

Why do we use propantheline? 

Propantheline belongs to the class of Anticholinergics and acts as an antispasmodic agent used to treat peptic ulcers.