propylhexedrine

Action and Spectrum

Actions and Spectrum 

propylhexedrine works by promoting the release of norepinephrine and dopamine, which are neurotransmitters in the brain.  

This leads to vasoconstriction in the nasal passages, reducing congestion and promoting airflow.

Drug Interaction

Adverse Reaction

Frequency not defined  

Stinging 

Burning 

Dryness 

Anxiety 

Sweating  

Rebound congestion 

Restlessness 

Tremor 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known hypersensitivity or allergy to propylhexedrine or any of its components should not use products containing propylhexedrine. 

Caution: 

• propylhexedrine can affect thyroid function and should be used cautiously in individuals with thyroid problems. 
• propylhexedrine is intended for short-term use to relieve nasal congestion. 
• Frequent or prolonged use may cause nasal congestion to recur or worsen so caution should be taken.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

propylhexedrine has vasoconstrictive effects. This can lead to an increase in blood pressure and heart rate.  

The increased release of norepinephrine and the resulting vasoconstriction contribute to cardiovascular stimulation.  

Pharmacodynamics 

Stimulation of alpha-1 adrenergic receptors leads to vasoconstriction and increased blood pressure. 

Stimulation of beta-1 adrenergic receptors increases heart rate and cardiac output. 

Pharmacokinetics 

Absorption   

When inhaled, propylhexedrine is absorbed through the mucous membranes of the nasal passages.  

Distribution 

propylhexedrine enters the bloodstream and is distributed throughout the body.  

Metabolism 

propylhexedrine is metabolized by the liver.  

Elimination and excretion 

The metabolites of propylhexedrine are excreted through the urine.

Adminstartion

Administration 

propylhexedrine is administered through nasal route and available in form of inhalers. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: propylhexedrine 

Why do we use propylhexedrine? 

propylhexedrine is widely used for its nasal decongestant properties.   

propylhexedrine is used to provide temporary relief from nasal congestion due to allergies, colds, or sinus congestion.