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Brand Name :
Benzedrex
Synonyms :
propylhexedrine
Class :
Decongestants, Intranasal
Dosage Forms & Strengths
Intranasal inhaler
250mg/actuation
Take 1 to 2 inhalations per nostril every 2 hours as required and not more than for 3 days
Dosage Forms & Strengths
Intranasal inhaler
250mg/actuation
for <6 years old: Not suggested
for ≥6 years old:
Take 1 to 2 inhalations per nostril every 2 hours as required and not more than for 3 days
Refer to adult dosing
Actions and Spectrum
propylhexedrine works by promoting the release of norepinephrine and dopamine, which are neurotransmitters in the brain.
This leads to vasoconstriction in the nasal passages, reducing congestion and promoting airflow.
Frequency not defined
Stinging
Burning
Dryness
Anxiety
Sweating
Rebound congestion
Restlessness
Tremor
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
propylhexedrine has vasoconstrictive effects. This can lead to an increase in blood pressure and heart rate.
The increased release of norepinephrine and the resulting vasoconstriction contribute to cardiovascular stimulation.
Pharmacodynamics
Stimulation of alpha-1 adrenergic receptors leads to vasoconstriction and increased blood pressure.
Stimulation of beta-1 adrenergic receptors increases heart rate and cardiac output.
Pharmacokinetics
Absorption
When inhaled, propylhexedrine is absorbed through the mucous membranes of the nasal passages.
Distribution
propylhexedrine enters the bloodstream and is distributed throughout the body.
Metabolism
propylhexedrine is metabolized by the liver.
Elimination and excretion
The metabolites of propylhexedrine are excreted through the urine.
Administration
propylhexedrine is administered through nasal route and available in form of inhalers.
Patient information leaflet
Generic Name: propylhexedrine
Why do we use propylhexedrine?
propylhexedrine is widely used for its nasal decongestant properties.
propylhexedrine is used to provide temporary relief from nasal congestion due to allergies, colds, or sinus congestion.
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