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Brand Name :
Trevintix
Synonyms :
Prothionamide, Protionamida, Protionamide, Protionamidum
Class :
Antibacterial, Antitubercular, Thiocarbamide derivative, Nicotinamide derivative
Brand Name :
Trevintix
Synonyms :
Prothionamide, Protionamida, Protionamide, Protionamidum
Class :
Antibacterial, Antitubercular, Thiocarbamide derivative, Nicotinamide derivative
Dosage forms& Strengths
Tablet
250 mg
This medication is used as a second-line treatment for active tuberculosis, a persistent bacterial illness brought on by Mycobacterium tuberculosis, in conjunction with other medications
The maximum amount that can be taken orally is 1g or 1000 mg, and the suggested dose is 15 to 20 mg/kg per day, or roughly 500 to 750 mg
Dose Adjustments
Limited data is available
Dosage Forms & Strengths
Tablet
250 mg
This active medication is used as a second-line treatment for tuberculosis, a persistent bacterial illness brought on by Mycobacterium tuberculosis, in conjunction with other medications
The maximum amount that can be taken orally is 500 mg, and the suggested dose per day is 15 to 20 mg/kg for 13 to 18-year-olds and 10 mg/kg one time a day for 2 to 12-year-olds
Refer to the adult dosing
prothionamide: they may increase the hypoglycemic effect of blood viscosity reducing agents
prothionamide: they may increase the hypoglycemic effect of blood viscosity reducing agents
may increase the hypoglycaemic effect of anti-diabetic agents
the combination of protionamide and acenocoumarol can increase the chances of bleeding
when protionamide is combined with ambroxol, the chances of methemoglobinemia may be increased
the chances of methemoglobinemia can be increased when protionamide is combined with articaine
when used with protionamide, the BCG vaccine's therapeutic benefit could be reduced
the chances of methemoglobinemia may be increased when protionamide is combined
the chances of methemoglobinemia can be increased when protionamide is combined with benzyl alcohol
when protionamide is combined with bupivacaine, the chances of methemoglobinemia may be increased
Actions and spectrum:
This is an antibiotic drug which exerts its mechanism of action by slowing down the bacterial growth in tuberculosis. It is known to work similarly to that of ethionamides. The spread of infection is reduced by preventing the further growth of bacteria and other pathogens.
Adverse reactions
Peripheral neuritis
Seizures
Psychotic disturbances
Tremors
Hallucination
Mental depression
Pellagra-like syndrome
Paresthesia
Dizzinesss
Drowsiness
Headache
Restlessness
Hepatitis
Stomatitis
Vomiting
Diarrhea
Nausea
Excessive salivation
Abdominal pain
Metallic taste
Weight loss
Transient raise in serum bilirubin
Anorexia
Olfactory disturbances
Blurred vision
Rash
Dermatitis
Optic neuritis
Acne
Purpura
Alopecia
Photosensitivity
Black box warning
Complete the course for the prescribed duration without any breaks
Contraindications/Caution
Contraindications
Hypersensitivity
Severe hepatic disorders
Cautions
Renal impairment
Hepatic impairment
Drug interactions
Pregnancy
Drug resistance
Breastfeeding
Pregnancy & breastfeeding:
Pregnancy consideration:
Safety study about the use of the drug in pregnancy is not available
Breastfeeding warnings:
Data about the excretion of the drug into human milk is not available
Pregnancy category:
Pharmacology:
Prothionamide is a derivative of thioamide indicated in treating MDR-tuberculosis.
Pharmacodynamics:
Prothionamide is often given as medicine for tuberculosis, but there are instances where it could work as well in leprosy situations. It helps reduce the speed at which diseases spread by stopping other germs or bacteria.
Pharmacokinetics:
Absorption
The time to achieve peak effect is 2 hours.
Distribution
The drug is known to be distributed widely into CSF and the body fluids.
Metabolism
It is known to undergo metabolism in liver and convert to sulfoxide and other metabolites.
Elimination and Excretion
Less than 1% of the drug is known to be excreted in urine.
Administration:
This is usually administered orally and recommended to take with food.
Patient information leaflet
Generic Name: prothionamide
Why do we use prothionamide?
This drug is used in treating multi-drug-resistant tuberculosis. It is considered as a second- line of treatment in tubercuolosis.
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