pyrantel tartrate

Action and Spectrum

Actions and Spectrum 

pyrantel tartrate acts as a neuromuscular blocking agent. It paralyzes the muscle cells of parasitic worms by interfering with the neurotransmission at the neuromuscular junction. This leads to the expulsion of the worms from the intestines through normal peristaltic movements.

Drug Interaction

Adverse Reaction

Frequency not defined  

Vomiting 

Diarrhea 

Stomach pain 

Nausea 

Headache 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• pyrantel tartrate should not be used in individuals who have a known hypersensitivity or allergy to its components. 

Caution: 

• Caution should be taken while using pyrantel tartrate in individuals with liver or kidney impairment. 
• Individuals with underlying health conditions should use pyrantel tartrate with caution. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

pyrantel tartrate works as a neuromuscular blocking agent. It paralyzes the muscle cells of parasitic worms by interfering with neurotransmission at the neuromuscular junction.  

pyrantel does not kill the worms and immobilizes them which allows the host’s immune system to remove them. 

Pharmacodynamics 

Activation of nicotinic receptors by pyrantel tartrate leads to depolarization of the muscle cells, causing a sustained contraction. 

This sustained contraction results in paralysis of the worm’s musculature. The paralysis of the worm’s musculature interferes with its ability to maintain attachment to the host’s intestinal wall. 

Pharmacokinetics 

Limited information available on ADME. 

Adminstartion

Administration 

pyrantel tartrate is taken orally in the form pellets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: pyrantel tartrate 

Why do we use pyrantel tartrate? 

pyrantel tartrate is used in the removal and control of infections from large and small strongyles.  

pyrantel tartrate is effective in treating infections caused by roundworms and pinworms.   

pyrantel tartrate is used in veterinary medicine to treat worm infections in animals, including dogs and horses.