pyrazinamide

Action and Spectrum

Drug Interaction

Adverse Reaction

1-10%: 

Anorexia 

Vomiting 

Malaise 

Nausea 

Arthralgia 

Myalgia 

<1%: 

Rash 

Fever 

Itching 

Gout 

Acne 

Dysuria 

Photosensitivity 

Hepatotoxicity 

Thrombocytopenia 

Interstitial nephritis 

Black Box Warning

Contraindication / Caution

Pyrazinamide is contraindicated in patients hypersensitive to the active ingredient. 

Pregnancy / Lactation

Pregnancy consideration:  

Category C. 

Breastfeeding warnings:  

The drug is excreted in breast milk. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category 

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: pyrazinamide 

Pronounced: pir-uh-ZIN-uh-mide 

Why do we use pyrazinamide? 

Pyrazinamide is an antitubercular agent. It is used to treat tuberculosis.