pyrimethamine

Action and Spectrum

Drug Interaction

Adverse Reaction

<1%: 

Frequency undefined: 

Abdominal cramps 

Abnormal skin pigmentation 

Anaphylaxis 

Anorexia 

Arrhythmias  

Atrophic glossitis 

Depression 

Fever 

Insomnia 

Lightheadedness 

Malaise 

Seizures 

Dermatitis 

Erythema multiforme 

Rash 

Stevens-Johnson syndrome 

Vomiting 

Diarrhea 

Xerostomia 

Megaloblastic anemia 

Leukopenia 

Pancytopenia 

Thrombocytopenia 

Pulmonary eosinophilia 

Neutropenia 

Black Box Warning

Contraindication / Caution

Pyrimethamine is contraindicated in people hypersensitive to it. 

Pregnancy / Lactation

Pregnancy consideration:  

Category C 

Breastfeeding warnings:  

Lactating mothers should not breastfeed during the therapy 

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: No evidence shows the risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women.    
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a product in humans; Pregnant women must take care of the potential risks. 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. The drug is not for pregnant women. 
• Category N: No data is available for the drug under this category. 

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet 

Generic Name: pyrimethamine  

Pronounced: pahy-ruh-meth-uh-meen 

Why do we use pyrimethamine? 

Pyrimethamine treats toxoplasmosis and P jiroveci Pneumonia.