Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
Accuretic
Synonyms :
quinapril/hydrochlorothiazide
Class :
ACE inhibitors and Diuretic Combos
Brand Name :
Accuretic
Synonyms :
quinapril/hydrochlorothiazide
Class :
ACE inhibitors and Diuretic Combos
Dosage forms & Strengths:
Adult:
Tablet
10mg/12.5mg
20mg/12.5mg
20mg/25mg
(10 mg/12.5 mg) or (20 mg/12.5 mg) orally each day Increase the dose from either of the drug components based on the clinical response Do not increase the hydrochlorothiazide part more than every 2-3 weeks
Dose Adjustments
Renal impairment- When CrCl ≥30 mL/min; no dose modification is required When CrCl <30 mL/min/1.73 m² or the serum creatinine ≥3 mg/dL, the drug is not recommended
Safety and efficacy not establishedÂ
Frequency undefined:
1-10%:
quinapril
Headache (2-6%)
Dizziness (4-8%)
Hypotension (3%)
Fatigue (3%)
Cough (2-4%)
Nausea/vomiting (1-2%)
Rash (1%)
Hyperkalemia (2%)
Chest pain (2%)
Myalgia (2-5%)
Back pain (1%)
Hyperkalemia (2%)
Frequency undefined:
quinapril
Acute renal failure
Alopecia
Angioedema
Angina
Hyperkalemia
Pancreatitis
hydrochlorothiazide
Anorexia
Epigastric distress
Hypotension
Anaphylaxis
Anemia
Orthostatic hypotension
Photosensitivity
Confusion
Erythema multiforme
Stevens-Johnson syndrome
Hypomagnesemia
Headache
Dizziness
Hyperuricemia
Black Box Warning:
If pregnancy is detected, discontinue the dose as soon as possible. The drug affects the RAS, causing oligohydramnios. It may result in injury/death of the fetus.
Contraindication/Caution:
Contraindications:
Contraindication in pregnancy: quinapril/hydrochlorothiazide is contraindicated during pregnancy, as it can cause harm to the developing fetus.
Contraindication in patients with a history of angioedema: quinapril/hydrochlorothiazide is contraindicated in patients with a history of angioedema, a condition characterized by swelling of the face, lips, tongue, and throat. It is because quinapril can increase the risk of angioedema, which can be life-threatening in some cases.
Cautions:
Pregnancy consideration:
Category C (in 1st trimester); D (in 2nd & 3rd trimester)
Breastfeeding warnings:
The drug is excreted in breast milk. Use the drug with caution during lactation.
Pregnancy category:
Category A: well-controlled and satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
quinapril works by inhibiting the action of the angiotensin-converting enzyme (ACE), an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that causes blood vessels to narrow, which increases blood pressure. By blocking the action of ACE, quinapril reduces the levels of angiotensin II, leading to vasodilation (widening of blood vessels) and a decrease in blood pressure.
Pharmacodynamics:
quinapril is an angiotensin-converting enzyme (ACE) inhibitor. ACE is an enzyme that converts angiotensin I to angiotensin II, a potent vasoconstrictor that increases blood pressure by causing the blood vessels to narrow. quinapril inhibits the activity of ACE, which leads to a decrease in the levels of angiotensin II. This, in turn, causes vasodilation, or the widening of the blood vessels, leading to a decrease in blood pressure.
hydrochlorothiazide is a thiazide diuretic that works by inhibiting the reabsorption of sodium and chloride in the kidneys. It leads to an increase in urine output and a decrease in blood volume, which reduces the workload on the heart and blood vessels and decreases blood pressure.
Pharmacokinetics:
quinapril
hydrochlorothiazide
Administration:
quinapril/hydrochlorothiazide is taken once daily, with or without food. The tablet should be swallowed whole with a full glass of water. The dose may be adjusted based on the patient’s blood pressure response, but the maximum recommended dose is 40 mg of quinapril and 25 mg of hydrochlorothiazide per day.
Patient information leaflet
Generic Name: quinapril/hydrochlorothiazide
Pronounced: KWIN-a-pril HYE-droe-KLOR-oh-THYE-a-zide
Why do we use quinapril/hydrochlorothiazide?
quinapril/hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension). It contains two active ingredients:
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