rhein

Action and Spectrum

Actions and Spectrum 

Rhein neutralizes free radicals in the body potentially providing protection against oxidative stress. 

Rhein has shown antimicrobial activity against certain bacteria and fungi.   

Drug Interaction

Adverse Reaction

Frequency not defined  

Diarrhea  

Black Box Warning

Black Box Warning 

None  

Contraindication / Caution

Contraindication/Caution: 

Pregnant and breastfeeding women should avoid rhein use while individuals with kidney problems or impairment should use it cautiously as well as those with hypokalemia. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Pharmacodynamics 

Rhein is a laxative which increases intestinal motility, promotes bowel movements, inhibits pro-inflammatory cytokines and enzymes, and exhibits anti-inflammatory effects by modulating inflammatory pathways. 

Pharmacokinetics 

Absorption   

Well Absorbed. 

Distribution 

Distributed throughout the body. 

Metabolism 

Metabolized in liver. 

Elimination and excretion 

Excreted through kidneys and urine. 

Adminstartion

Administration 

Rhein is given orally in the form of capsules and liquid formulations.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: rhein 

Why do we use rhein? 

Rhein treats hepatic disease, osteoarthritis, and atherosclerosis. Its hepatoprotective effects protect the liver from damage and making it a valuable treatment option.