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Brand Name :
N/A
Synonyms :
ritivixibat
Class :
Ileal bile acid transporter (IBAT) inhibitor
Brand Name :
N/A
Synonyms :
ritivixibat
Class :
Ileal bile acid transporter (IBAT) inhibitor
Dosage Forms & StrengthsÂ
It is under investigation for the treatment of liver diseases, cardiovascular disorders, gastrointestinal disorders, and liver diseases, like Alagille syndrome and PFICÂ
It is an investigational drug, and is developed for the treatment of several cholestatic liver diseases, including Alagille syndrome and progressive familial intrahepatic cholestasis (PFIC)
Cardiovascular diseases, disorders of fatty acid metabolism and glucose utilization, gastrointestinal disorders, and liver diseases can all be treated with this drug
Not determined Â
Refer to adult dosingÂ
Actions and SpectrumÂ
Ritivixibat is a bile acid transport inhibitor that inhibits bile acid reabsorption in ileum and increasing bile acid excretion in feces.Â
Frequency not definedÂ
NoneÂ
Black Box WarningÂ
None
Contraindication/Caution:Â
None
Pregnancy/LactationÂ
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknownÂ
Pregnancy Categories:Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experimentsÂ
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
PharmacologyÂ
Ritivixibat inhibits bile acid transportation in ileum and increases the bile acid excretion, thereby decreasing bile acid reabsorption in the intestines.Â
PharmacodynamicsÂ
ritivixibat reduces the liver damage from the liver cholestatic diseases like alagille syndrome and PFIC by decreasing bile acid reabsorption and promoting the feces elimination.Â
PharmacokineticsÂ
Limited information available on ADME.Â
AdministrationÂ
The administration of ritivixibat is not known.Â
Patient information leafletÂ
Generic Name: ritivixibatÂ
Why do we use ritivixibat?Â
Ritivixibat inhibits bile acid transport in ileum, reducing bile acid reabsorption in intestine, aiming to lower the bile acid toxic levels in liver and increase liver damage.Â
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