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December 18, 2025
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Brand Name :
N/A
Synonyms :
rovadicitinib
Class :
JAK/ROCK inhibitor
Brand Name :
N/A
Synonyms :
rovadicitinib
Class :
JAK/ROCK inhibitor
Dosage Forms & Strengths
Tablet
5 mg
10 mg
Myeloproliferative Neoplasm (MPN) (off-label)
Currently in phase 2 clinical trial in the treatment of Myelofibrosis and also in patients with palpable splenomegaly and MPN
The dose used in the study is 5 mg four times per day or 10 mg two times a day for four weeks, which showed good therapeutic response, which was well tolerated and is safe
:
Dose Adjustments
Limited data is available
Safety and efficacy are not established
Refer to the adult dosing
Actions and Spectrum:
Actions:
Rovadicitinib, a novel oral JAK/ROCK inhibitor, triggers cell death, slows cell growth, and lowers inflammatory cytokines by targeting the JAK-STAT pathway in preclinical trials.
Spectrum:
Rovadicitinib is effective and safe for myelofibrosis patients, especially those with enlarged spleens.
Frequency defined
Platelet count reduction (17.72%)
Anemia (16.46%)
Black box warning
None
Contraindication/Caution:
Contraindications
Hypersensitivity
Cautions
Renal impairment
Hepatic impairment
Pregnancy & Breastfeeding
Pregnancy/lactation
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Rovadicitinib, a novel oral JAK/ROCK inhibitor.
Pharmacodynamics:
Rovadicitinib, a novel oral JAK/ROCK inhibitor, triggers cell death, slows cell growth, and lowers inflammatory cytokines by targeting the JAK-STAT pathway in preclinical trials.
Pharmacokinetics:
Absorption
The AUC & peak concentrations of rovadicitinib increase with dosage.
Elimination and Excretion
The half-life is 1.3 hours
Administration:
The route of administration is oral.
Patient information leaflet
Generic Name: rovadicitinib
Pronounced: roh-vuh-DI-si-ti-nib
Why do we use rovadicitinib?
Rovadicitinib is undergoing phase 2 trial in China, comparing its safety and effectiveness to hydroxyurea in myelofibrosis patients.
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